Hormonal Control of Lactation
Hormonal Control of Lactation
复制标题
哺乳期的荷尔蒙控制
DOI：
10.1007/978-3-642-81389-4
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
I. Hart
中科院分区：
文献类型：
--
作者：
A. T. Cowie;I. Forsyth;I. Hart
这本专著的主题--关于泌乳的激素控制的研究--长期以来一直是这个实验室的主要兴趣。这项研究是在20世纪30年代中期由已故的弗利教授发起的，他以极大的热情和奉献精神指导了这项工作，直到1970年英年早逝。近年来，这一富有成果的基础和应用研究领域引起了广泛关注；出现了许多令人振奋的事件和发展，出版物数量急剧增加。这些事件是多种多样的，包括对人催乳素的鉴定、分离和测序；在几个反刍动物物种中鉴定和分离胎盘催乳素，认识到它们在乳房生长和分化中的重要性；采用高灵敏的生物测定、放射免疫和放射受体测定技术测定乳汁营养激素；临床上越来越多地认识到初乳和牛奶对新生儿的免疫和营养重要性；加强对正常乳房发生的研究，为乳腺癌的研究奠定坚实的基础；以及开发具有独特分化模式和多种合成能力的乳腺，将其作为研究荷尔蒙控制酶和分泌蛋白合成的基本机制的宝贵组织；以及激素-受体相互作用的研究。
Research on the hormonal control oflactation-the subject of this monograph-has long been the major interest of this laboratory. Studies were initiated in the mid 1930s by the late Professor S. 1. Folley, FRS, who directed the work with immense enthusiasm and devotion until his untimely death in 1970. This fruitful area of basic and applied research has, in recent years, attracted widespread attention; there have been many exciting events and developments with a dramatic increase in the number of publications. These events are diverse and include the identification, isolation and sequencing of human prolactin; the identification and isolation of placentallactogens in several ruminant species with recognition of their importance in mammary growth and differentiation; the introduction of highly sensitive bioassay, radioimmuno-and radioreceptor-assay techniques for mammotrophic hormones; the growing clinical appreciation of the immunological and nutritional importance of colostrum and milk to the newborn; the intensification of studies on normal mammogenesis to establish a sound basis for studies on mammary cancer; and the exploitation of the mammary gland, with its characteristic differentiation patterns and multiple synthetic abilities, as a valuable tissue for the investigation of basic mechanisms involved in the synthesis under hormonal control of enzymes and secretory proteins; and for the study of hormone-receptor interactions.