Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study
Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study
复制标题
DOI：
10.1111/j.0042-9007.2003.00373.x
复制
发表时间：
2003-01-01
期刊：
影响因子：
2.7
通讯作者：
Wiesneth, M
中科院分区：
文献类型：
--
作者：
Bux, J;Cassens, U;Wiesneth, M
对183名献血者的507份粒细胞捐献资料进行了评估。未观察到粒细胞集落刺激因子(G-CSF)相关的严重副作用。三名捐献者抱怨输注羟乙基淀粉(HES)后出现严重瘙痒。高比例(85%)的献血者表示愿意再次捐献粒细胞。平均粒细胞产率为4.3×10(10)。与低相对分子质量的HES相比，高相对分子质量的HES的产率显著提高。在16%的受者中观察到轻微但没有严重的输血不良反应。白细胞同种异体免疫率为24%。供者和受者分别对G-CSF刺激和G-CSF动员的粒细胞输注耐受性良好
Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony-stimulating factor (G-CSF)-related side-effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4.3 x 10(10). High-molecular-weight HES resulted in a significantly higher yield compared with low-molecular-weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G-CSF stimulation and transfusion of G-CSF-mobilized granulocytes were well tolerated by donors and recipients, respectively