Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo
Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo
复制标题
DOI：
10.1016/j.bmcl.2012.01.102
复制
发表时间：
2012-03-15
影响因子：
2.7
通讯作者：
Liu, Jiangning
中科院分区：
文献类型：
--
作者：
Yang, Yajun;Zhang, Lianfeng;Liu, Jiangning
人类肠道病毒71型感染会导致6岁以下儿童出现手足口病，并在亚太地区大规模暴发中造成死亡。目前临床上尚无针对肠道病毒71型的有效疫苗或抗病毒药物。在这项研究中，我们在体外和体内研究了香叶素对肠道病毒 71 型的抗病毒作用。结果表明，香叶苷能有效抑制横纹肌肉瘤细胞中的病毒复制，IC50为10μg/ml。此外，用香叶素治疗受到致死剂量肠道病毒 71 攻击的小鼠可降低死亡率，缓解临床症状，并抑制肌肉组织中的病毒复制。结果表明，香叶素可能作为抗肠道病毒71的潜在药物。(C) 2012 Elsevier Ltd.保留所有权利。
Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic. In this study, we investigated the antiviral effect of geraniin on enterovirus 71 both in vitro and in vivo. The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC50 of 10 mu g/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. The results suggest that geraniin may be used as a potential drug for anti-enterovirus 71. (C) 2012 Elsevier Ltd. All rights reserved.