MATCHED CASE-CONTROL DESIGNS AND OVERMATCHED ANALYSES
MATCHED CASE-CONTROL DESIGNS AND OVERMATCHED ANALYSES
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DOI：
10.1093/oxfordjournals.aje.a114443
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发表时间：
1986-10-01
影响因子：
5
通讯作者：
LINET, M
中科院分区：
文献类型：
--
作者：
BROOKMEYER, R;LIANG, KY;LINET, M
在1：1配对病例对照研究中，几个配对可能有相同的匹配标准。本文的目的是考虑在这种情况下估计优势比的各种分析方法。一种方法是执行通常的配对分析；另一种方法是将配对组合成地层，并计算条件最大似然或Mantel-Haenszel估计。基于理论和模拟结果的配对分析可能会给出误导性的推断，尽管它的平均性能几乎与分层分析一样好。匹配对分析偶尔表现不佳的原因是，由于地层内的随机配对，可能会获得极端数量的不协调对。得出的结论是，谨慎的政策是进行分层分析而不是配对分析，即使是以额外的计算为代价。
In a 1:1 matched-pairs case-control study, several pairs may have the same matching criteria. The objective of this paper is to consider various analytic approaches for odds ratio estimation in this situation. One approach is to perform the usual matched-pairs analysis; the alternative is to combine pairs into strata and compute the conditional maximum likelihood or Mantel-Haenszel estimate. Matched-pairs analysis based on theoretic and simulation results may give misleading inferences, although on average it performs nearly as well as the stratified analysis. The occasional poor performance of the matched-pairs analysis results from the possibility of obtaining an extreme number of discordant pairs due to the random pairing within a stratum. It is concluded that the prudent policy is to perform a stratified rather than a paired analysis, even at the expense of additional computation.