Association of the hCLCA1 gene with childhood and adult asthma
Association of the hCLCA1 gene with childhood and adult asthma
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DOI：
10.1038/sj.gene.6364124
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发表时间：
2004-11-01
影响因子：
5
通讯作者：
Matsubara, Y
中科院分区：
文献类型：
--
作者：
Kamada, F;Suzuki, Y;Matsubara, Y
哮喘是由支气管炎症引起的。这种炎症包括粘液分泌过多和分泌过多。最近，一项小鼠哮喘模型研究表明，gob-5参与了哮喘的发病机制。gob-5基因参与粘液分泌，在致敏小鼠中抗原攻击时其表达上调。这一观察结果表明，gob-5的人类同源物hCLCA1（人类钙依赖性氯离子通道-1）可能与人类疾病有关。我们在日本人群中筛选了hCLCA1的单核苷酸多态性（snp）。我们确定了8个snp，并对384名儿童哮喘患者、480名成人哮喘患者和672名对照组进行了关联研究。在单倍型分析中，我们发现对照组和儿童哮喘的单倍型分布模式不同(P
Asthma is caused by bronchial inflammation. This inflammation involves mucus overproduction and hypersecretion. Recently, a mouse model of asthma showed that gob-5 is involved in the pathogenesis of asthma. The gob-5 gene is involved in mucus secretion and its expression is upregulated upon antigen attack in sensitized mice. The observation suggests that human homologue of gob-5, hCLCA1 (human calcium-dependent chloride channel-1), may be involved in human disease. We screened for single-nucleotide polymorphisms (SNPs) in hCLCA1 in the Japanese population. We identified eight SNPs, and performed association studies using 384 child patients with asthma, 480 adult patients with asthma, and 672 controls. In haplotype analysis, we found a different haplotype distribution pattern between controls and childhood asthma (P