Electron microscopic studies of anterior pituitary glands of vitamin E-deficient male mice.
Electron microscopic studies of anterior pituitary glands of vitamin E-deficient male mice.
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作者：
I. Ichihara
许多工作者在光镜下观察了维生素E缺乏引起的雄性动物垂体前叶的组织学变化。然而，这些观察的结果尚未确定。货车Wagenen（1925），纳尔逊（1933），Muller & Muller（1937），巴里（1937），比德杜尔夫&迈耶（1941）和Griesbach，Bell &利文斯顿（1957）曾报道，喂食这种饲料的雄性大鼠的垂体出现去势变化; Herrick、艾德和斯诺（1952）报道了活性嗜碱细胞数量的减少，而李（1960）发现“去势”变化并不明显，但出现了增大的嗜酸细胞。最近用电子显微镜研究了小鼠垂体前叶的细胞学（巴恩斯，1962;巴恩斯，1963; Ichihara，1967），巴恩斯（1963）通过研究发情、去势和甲状腺素处理的小鼠，综述了六种已知腺垂体激素中五种的细胞起源。因此，在以前工作的基础上，有可能进行目前的研究维生素E缺乏对垂体前叶超微结构的影响，特别是激素功能。
The histological changes in anterior pituitary glands induced by vitamin Edeficient diet in male animals have been observed by many workers with the light microscope. However, the results of these observations are not yet definite. Van Wagenen (1925), Nelson (1933), Muller & Muller (1937), Barrie (1937), Biddulph & Meyer (1941) and Griesbach, Bell & Livingston (1957) have reported that the pituitaries of male rats fed such a diet showed castration changes; Herrick, Eide & Snow (1952) reported a reduced number of active basophilis, while Lee (1960) found that 'castration' changes are not so marked, but that enlarged acidophil cells appear. The cytology of the anterior pituitary of the mouse has recently been studied electron microscopically (Barnes, 1962; Barnes, 1963; Ichihara, 1967), and Barnes (1963) reviewed the cellular origins of five of six known adenohypophysial hormones, studying oestrous, castrated and thyroxine-treated mice. Thus, on the basis of former work, it has been possible to undertake the present study of the effect of vitamin E-deficiency upon the ultrastructure of the anterior pituitaries, with special reference to hormonal function.