Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces
Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces
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全面了解癌症力学生物学：生物物理力下的钙、YAP 和 microRNA
DOI：
10.1039/d1sm01618k
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发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Tang, Xin
中科院分区：
文献类型：
--
作者：
Liang, Chenyu;Huang, Miao;Li, Tianqi;Li, Lu;Sussman, Hayley;Dai, Yao;Siemann, Dietmar W.;Xie, Mingyi;Tang, Xin
越来越多的研究表明，在肿瘤进展的不同阶段，组织中的微环境力学和驻留肿瘤细胞中的生物化学-遗传活性之间的相互作用具有重要作用。组织微环境中的生物力学信号通过分子力学传感器或传感器传递到肿瘤细胞，并通过力学转导过程调节生物化学反应和基因表达。然而，机械转导过程和细胞内生化信号通路之间的分子相互作用仍然难以捉摸。本文综述了肿瘤进展过程中生物力学信号与钙离子（Ca 2+）、yes相关蛋白（雅普）和microRNA（miRNAs）之间相互作用的最新研究进展。我们解决的分子机制之间的相互作用的mechanotransductionpathways和每三个效应。此外，我们讨论了软物质和机械生物学的背景下，三个效应器之间的功能相互作用。最后，我们提出了未来的方向，研究肿瘤mechanobiology，可以采用钙，雅普，和miRNA作为新的策略，癌症mechanotheraputics。该框架有可能为开发新的下一代癌症疗法以抑制和治疗肿瘤带来见解。
An increasing number of studies have demonstrated the significant roles of the interplay between microenvironmental mechanics in tissues and biochemical-genetic activities in resident tumor cells at different stages of tumor progression. Mediated by molecular mechano-sensors or -transducers, biomechanical cues in tissue microenvironments are transmitted into the tumor cells and regulate biochemical responses and gene expression through mechanotransduction processes. However, the molecular interplay between the mechanotransduction processes and intracellular biochemical signaling pathways remains elusive. This paper reviews the recent advances in understanding the crosstalk between biomechanical cues and three critical biochemical effectors during tumor progression: calcium ions (Ca2+), yes-associated protein (YAP), and microRNAs (miRNAs). We address the molecular mechanisms underpinning the interplay between the mechanotransduction pathways and each of the three effectors. Furthermore, we discuss the functional interactions among the three effectors in the context of soft matter and mechanobiology. We conclude by proposing future directions on studying the tumor mechanobiology that can employ Ca2+, YAP, and miRNAs as novel strategies for cancer mechanotheraputics. This framework has the potential to bring insights into the development of novel next-generation cancer therapies to suppress and treat tumors.