Potential Role of Fluoroquinolone Therapy in Childhood Otitis Media

Potential Role of Fluoroquinolone Therapy in Childhood Otitis Media
复制标题

氟喹诺酮类药物治疗儿童中耳炎的潜在作用

DOI:
--
复制
发表时间:
2004
期刊:
The Pediatric Infectious Disease Journal
影响因子:
--
通讯作者:
U. Schaad
U. Schaad
中科院分区:
--
文献类型:
--
作者:
R. Dagan;A. Arguedas;U. Schaad

文献摘要

参考文献

被引文献

相似文献

肺炎球菌和其他病原体对现有抗生素的耐药性增加引起了人们对急性中耳炎儿童细菌学和临床失败的担忧。对于反复感染或近期治疗失败的患者,几乎没有治疗选择。在儿科和儿科研究中同情使用氟喹诺酮类药物的有限经验并未与关节毒性(儿童的主要安全问题)明确联系起来。较新的 8-甲氧基氟喹诺酮类药物可能在与多重耐药病原体相关的特定病例中发挥作用。
Increased resistance of pneumococci and other pathogens to available antibiotics raises concerns about bacteriologic and clinical failure in children with acute otitis media. Few therapeutic options exist for patients with recurrent infections or recent treatment failure. The limited experience from the compassionate use of fluoroquinolones in pediatrics and pediatric studies has not been linked unequivocally with arthrotoxicity, the primary safety concern in children. Newer 8-methoxyfluoroquinolones may have a role in selected cases associated with multidrug-resistant pathogens.
口服加替沙星治疗门诊社区获得性肺炎:来自 TeqCES 的结果,这是一项基于社区的开放标签多中心研究。
DOI: 10.1016/s0732-8893(02)00447-9
发表时间: 2002
影响因子: 2.9
作者:
Gotfried,Mark;Quinn,ThomasC;Gothelf,Samantha;Wikler,MatthewA;Webb,CDouglas;Nicholson,SusanC
通讯作者: Nicholson,SusanC