Transition-metal-free regioselective synthesis of alkylboronates from arylacetylenes and vinyl arenes
Transition-metal-free regioselective synthesis of alkylboronates from arylacetylenes and vinyl arenes
复制标题
DOI：
10.1039/c5gc02633d
复制
发表时间：
2016-02
期刊：
影响因子：
9.8
通讯作者：
Kai Yang;Q. Song
中科院分区：
文献类型：
--
作者：
Kai Yang;Q. Song
以芳基乙炔或乙烯基芳烃和双（pinacolato）二硼为原料，通过串联硼化和原硼化反应合成了一种无过渡金属的烷基硼酸盐。该反应高效、实用、环保，可制得具有优异的区域选择性、广泛的官能团耐受性和优良的小、克级收率的反马氏产物。
A transition-metal-free synthesis of alkylboronates, utilizing arylacetylenes or vinyl arenes and bis(pinacolato)diboron through tandem borylation and protodeboronation, has been developed. This reaction is efficient, practical and environmentally benign, leading to anti-Markovnikov products with excellent regioselectivity, broad functional group tolerance and excellent yields in both small and gram scales.