New approaches for understanding mechanisms of drug resistance in schistosomes.
New approaches for understanding mechanisms of drug resistance in schistosomes.
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DOI：
10.1017/s0031182013000231
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发表时间：
2013-10
期刊：
影响因子：
2.4
通讯作者：
Greenberg RM
中科院分区：
文献类型：
--
作者：
Greenberg RM
血吸虫是引起血吸虫病的寄生扁虫，血吸虫病是一种被忽视的热带疾病，影响着全世界数亿人。血吸虫病的治疗和控制几乎完全依赖于单一药物吡喹酮（PZQ），这使得出现耐药性的前景尤其令人担忧。本综述将调查血吸虫和其他扁形动物对 PZQ（和其他药物）耐药性的报告，并探讨可能产生耐药性的机制。将讨论新的基因组和后基因组策略，这些策略有望更好地理解这些生物体中如何产生耐药性。这些方法还可以深入了解这些药物的作用方式，并有可能为监测耐药性的出现提供标记。
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical disease that affects hundreds of millions worldwide. Treatment and control of schistosomiasis relies almost entirely on the single drug praziquantel (PZQ), making the prospect of emerging drug resistance particularly worrisome. This review will survey reports of PZQ (and other drug) resistance in schistosomes and other platyhelminths, and explore mechanisms by which drug resistance might develop. Newer genomic and post-genomic strategies that offer the promise of better understanding of how drug resistance might arise in these organisms will be discussed. These approaches could also lead to insights into the mode of action of these drugs and potentially provide markers for monitoring the emergence of resistance.