Skeletal muscle function during hypocaloric diets and fasting: a comparison with standard nutritional assessment parameters.
Skeletal muscle function during hypocaloric diets and fasting: a comparison with standard nutritional assessment parameters.
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低热量饮食和禁食期间的骨骼肌功能：与标准营养评估参数的比较。
DOI：
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发表时间：
1983
影响因子：
7.1
通讯作者：
K. Jeejeebhoy
中科院分区：
文献类型：
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作者：
D. Russell;Lawrence A Leiter;J. Whitwell;E. Marliss;K. Jeejeebhoy
对6例肥胖患者的骨骼肌功能和标准营养评估参数进行了测量。在维持体重的饮食中进行基线测量，并在400卡路里饮食2周后进行进一步测量，随后禁食2周，然后再喂养2周。拇收肌的功能通过电刺激尺神经来评估。测量的肌肉功能的客观参数是：1）收缩力，表示为在10、20、30、50和100 Hz下电刺激获得的最大力的百分比。2)最大松弛速率表示为力损失百分比/10 ms。3）耐力表示为力损失百分比/30 s。还测量了标准营养评估参数（血清白蛋白和转铁蛋白、肌酐身高指数、人体测量和全身氮和钾）。400-cal饮食2周后，10 Hz下的收缩力从基线29.6 +/- 1.0%显著增加至49.0 +/- 2.8%（平均值+/- SEM）（p <0.01）。在400卡路里饮食2周后，最大松弛率从基线9.8 +/- 0.03%力损失/10 ms显著减慢至8.2 +/0 0.3%力损失/10 ms（平均值+/- SEM）（p <0.01）。再禁食2周后，这些肌肉功能异常持续存在。禁食后，肌力损失从基线3.9 +/- 0.8%力损失/30 s显著增加至13.7 +/- 3.4%力损失/30 s（平均值+/- SEM）（P <0.01）。再喂养2周后，测量的肌肉功能的所有方面均正常。在研究期间，标准营养评估参数没有显著变化。
Skeletal muscle function and standard nutritional assessment parameters were measured in six obese patients. Base-line measurements were made on a weight-maintaining diet, and further measurements after 2 wk of a 400-cal diet, followed by 2 wk of fasting and then after 2 wk of refeeding. The function of the adductor pollicis muscle was assessed by electrical stimulation of the ulnar nerve. The objective parameters of muscle function measured were: 1) force of contraction expressed as a percentage of the maximal force obtained with electrical stimulation at 10, 20, 30, 50, and 100 Hz. 2) Maximal relaxation rate expressed as percentage force loss/10 ms. 3) Endurance expressed as percentage force loss/30 s. Standard nutritional assessment parameters (serum albumin and transferrin, creatinine height index, anthropometry and total body nitrogen and potassium) were also measured. There was a significant increase in the force of contraction at 10 Hz from a base-line of 29.6 +/- 1.0% to 49.0 +/- 2.8% (mean +/- SEM) after 2 wk of a 400-cal diet (p less than 0.01). These was a significant slowing of the maximal relaxation rate from a base-line of 9.8 +/- 0.03% force loss/10 ms to 8.2 +/0 0.3% force loss/10 ms (mean +/- SEM) (p less than 0.01) after 2 wk of a 400-cal diet. After a further 2 wk of fasting these abnormalities in muscle function persisted. There was a significant increase in muscle force loss from a base-line of 3.9 +/- 0.8% force loss/30 s to 13.7 +/- 3.4% force loss/30 s (mean +/- SEM) after fasting (P less than 0.01). After 2 wk of refeeding all aspects of muscle function measured were normal. During the study the standard nutritional assessment parameters did not change significantly.