More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder
More optimal but less regulated dorsal and ventral visual networks in patients with major depressive disorder
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重度抑郁症患者的背侧和腹侧视觉网络更优化但监管更少
DOI：
10.1016/j.jpsychires.2019.01.005
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发表时间：
2019-03-01
影响因子：
4.8
通讯作者：
Deng, Yanjia
中科院分区：
文献类型：
--
作者：
Chen, Hui;Liu, Kai;Deng, Yanjia
以往的研究表明，重度抑郁障碍(MDD)可以深刻地改变大脑的视觉皮质和视觉注意系统。然而，关于全网络水平异常的具体模式还知之甚少。在这项研究中，收集了159名参与者的静息状态功能磁共振成像数据，其中包括86名未服用药物的MDD患者和73名匹配的健康对照组。背侧/腹侧视觉网络的定义是基于我们之前发表的来自激活似然估计分析的大脑坐标。分别计算和比较了MDD组和对照组的静态和动态网络特性。此外，还分析了背侧注意网络(DAN)和两个视觉网络之间的多变量距离相关量化的网络连通性。结果表明，与对照组相比，MDD患者的两个视觉网络均具有明显的聚集性(背侧：P=0.002；腹侧：P=0.004)和更高的小世界(背侧：P=0.001；腹侧：P=0.002)。MDDS的两个神经网络的动态功能连接的平均变异性都较高(背侧：P<；0.001；腹侧：P=0.001)。此外，MDD组的两个视觉网络与DAN的网络间连通性降低(背侧：P=0.004；腹侧：P=0.013)。综上所述，这些结果可能支持抑郁病理作用下的腹侧和背侧视觉系统可能以自主性增强的状态为特征，即更优化、更经济、更有效的网络内组织，结合更多的独立性和更少的来自注意网络的外部调节，从而表明脑视觉系统在MDD中的功能增强。
Previous studies indicate that major depressive disorder (MDD) can profoundly modify the visual cortices as well as the visuo-attentional systems of brain. However, little is known on the specific pattern of the whole-network level abnormalities. In this study, resting-state functional magnetic resonance imaging data were collected from 159 participants, including 86 medication-free MDD patients and 73 matched healthy controls. The dorsal/ ventral visual networks were defined based on our previously published brain coordinates from activation likelihood estimation analyses. The static and dynamic network properties were respectively calculated and compared between MDD and control groups. Moreover, the inter-network connectivities quantified using the multivariate distance correlation between the dorsal attention network (DAN) and the two visual networks were also analyzed. Results indicated that both of the two visual networks in MDD were found with significantly increased clustering coefficient (dorsal: p = 0.002; ventral: p = 0.004) and higher small-worldness (dorsal: p = 0.001; ventral: p = 0.002) as compared with control group. A higher mean variability of dynamic functional connectivity was found in both two networks in MDDs (dorsal: p < 0.001; ventral: p = 0.001). Moreover, the two visual networks in MDD group showed decreased inter-network connectivities to DAN (dorsal: p = 0.004; ventral: p = 0.013). Taken together, these results may support that the ventral and dorsal visual systems under the pathological effect of depression are possibly characterized by a status of increased autonomy, i.e., a more optimal, economical, and efficient intra-network organization combining with increased independency and receiving less outside regulation from attention network, thus indicating the increased functional role of the brain visual systems in MDD.