Pelvic fractures after radiotherapy for cervical cancer: implications for survivors.
Pelvic fractures after radiotherapy for cervical cancer: implications for survivors.
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DOI：
10.1002/cncr.24811
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发表时间：
2010-02-01
期刊：
影响因子：
6.2
通讯作者：
Sood, Anil K.
中科院分区：
文献类型：
--
作者：
Schmeler, Kathleen M.;Jhingran, Anuja;Iyer, Revathy B.;Sun, Charlotte C.;Eifel, Patricia J.;Soliman, Pamela T.;Ramirez, Pedro T.;Frumovitz, Michael;Bodurka, Diane C.;Sood, Anil K.
在接受宫颈癌根治性放疗的妇女中，确定骨盆骨折的发生率和相关的危险因素。2001年至2006年间，德克萨斯大学M。D.安德森癌症中心进行了审查。其中，300例患者至少有1项治疗后计算机断层扫描或磁共振成像研究可供审查，他们构成了我们的研究人群。所有影像学检查均由一名放射科医生重新审查，以评价骨折。300例患者中有29例（9.7%）发生骨盆骨折。骨折部位包括骶骨（n = 24; 83%）、骶骨和耻骨（n = 3; 10%）、髂嵴（n = 1; 3%）和骶骨和髋臼（n = 1; 3%）。13名患者（45%）有症状，疼痛是最常见的症状。从完成放疗到影像学检查发现骨折的中位时间为14.1个月（范围2.1-63.1个月），38%的患者在完成治疗后1年内确诊，83%的患者在2年内确诊。发生骨折的女性患者诊断时的中位年龄高于未发生骨折的女性患者（56.5岁vs 46.7岁; P = 0.04）。绝经后妇女骨折的比例更高（62%比37%; P = 0.03）。骨折妇女的中位体重指数较低（26.0 kg/m2 vs 28.0 kg/m2; P = 0.03）。在宫颈癌放疗后，很大一部分妇女发现骨盆骨折。应考虑对这些妇女进行骨密度筛查和药物干预。
The incidence of pelvic fractures and associated risk factors was determined in women treated with curative-intent radiotherapy for cervical cancer. The records of 516 women treated with curative-intent radiotherapy for cervical cancer between 2001 and 2006 at the University of Texas M. D. Anderson Cancer Center were reviewed. Among these, 300 patients had at least 1 post-treatment computed tomography scan or magnetic resonance imaging study available for review, and they comprised our study population. All imaging studies were re-reviewed by a single radiologist to evaluate for fractures. Pelvic fractures were noted in 29 of 300 patients (9.7%). Fracture sites included sacrum (n = 24; 83%), sacrum and pubis (n = 3; 10%), iliac crest (n = 1; 3%), and sacrum and acetabulum (n = 1; 3%). Thirteen patients (45%) were symptomatic, with pain being the most common presenting symptom. The median time from the completion of radiotherapy to the detection of fractures on imaging studies was 14.1 months (range, 2.1–63.1 months), with 38% of patients diagnosed within 1 year and 83% diagnosed within 2 years of completing therapy. The median age of the patients at diagnosis was higher in the women who developed a fracture compared with the women who did not (56.5 years vs 46.7 years; P = .04). A higher number of women with a fracture were postmenopausal (62% vs 37%; P = .03). The median body mass index was lower in the women who had a fracture (26.0 kg/m2 vs 28.0 kg/m2; P = .03). Pelvic fractures were detected in a substantial proportion of women after radiotherapy for cervical cancer. Bone mineral density screening and pharmacologic intervention should be considered in these women.
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影响因子：
120.7
作者：
Baxter, NN;Habermann, EB;Virnig, BA
通讯作者：
Virnig, BA
影响因子：
3.5
作者：
Asomaning, Kofi;Bertone-Johnson, Elizabeth R.;Pekow, Penelope S.
通讯作者：
Pekow, Penelope S.
DOI：
10.1016/j.ijrobp.2007.08.005
发表时间：
2008-03-15
影响因子：
7
作者：
Oh, Dongryul;Huh, Seung Jae;Lee, Je Ho
通讯作者：
Lee, Je Ho
影响因子：
--
作者：
Wu, F;Mason, B;Reid, IR
通讯作者：
Reid, IR
影响因子：
4.7
作者：
Huh, SJ;Kim, B;Ahn, YC
通讯作者：
Ahn, YC