Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae.
Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae.
复制标题
巨胞饮作用是淋病奈瑟菌进入原代人尿道上皮细胞的机制。
DOI：
10.1128/iai.68.3.1696-1699.2000
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发表时间：
2000
影响因子：
3.1
通讯作者：
Apicella,MA
中科院分区：
文献类型：
--
作者：
Zenni,MK;Giardina,PC;Harvey,HA;Shao,J;Ketterer,MR;Lubaroff,DM;Williams,RD;Apicella,MA
Gonococcal entry into primary human urethral epithelial cells (HUEC) can occur by macropinocytosis. Scanning and transmission electron microscopy revealed lamellipodia surrounding gonococci, and confocal laser scanning microscopy analysis showed organisms colocalized withMr70,000 fluorescein isothiocyanate-labeled dextran within the cells. Phosphoinositide 3-kinase inhibitors and an actin polymerization inhibitor prevented macropinocytic entry of gonococci into HUEC.
