Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia
Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia
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DOI：
10.1002/path.5208
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发表时间：
2019-04-01
影响因子：
7.3
通讯作者：
Shibata, Tatsuhiro
中科院分区：
文献类型：
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作者：
Rokutan, Hirofumi;Abe, Hiroyuki;Shibata, Tatsuhiro
胃癌（GC）是最常见和危及生命的恶性肿瘤之一。GCs的病程和肿瘤侵袭性各不相同，尽管如何决定早期命运以及由哪些因素决定仍然是难以捉摸的。为了解决这个问题，我们收集了43例胃粘膜内瘤变（GINs），包括不典型增生/上皮内瘤变（D/IEN，一种癌前病变）和微小胃癌(miGC；
Gastric cancer (GC) is one of the most common and life-threatening malignancies. The course of disease and tumor aggressiveness vary among GCs, although how early fate is determined and by what factors remains elusive. To solve this question, we collected 43 gastric intramucosal neoplasias (GINs), comprising dysplasia/intraepithelial neoplasia (D/IEN; a premalignant lesion) and minute GC (miGC;