Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior
Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior
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DOI：
10.1523/jneurosci.0804-06.2006
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发表时间：
2006-06-14
影响因子：
5.3
通讯作者：
Brugger, P
中科院分区：
文献类型：
--
作者：
Knoch, D;Gianotti, LRR;Brugger, P
决策需要仔细权衡与选择相关的风险和收益。一些人需要获得高额回报，以平衡即使是最小的风险，而另一些人则冒着巨大的风险，希望只获得最小的好处。我们在这里表明，冒险是一种依赖于右脑前额叶活动的可改变的行为。我们使用低频率、重复的经颅磁刺激来暂时扰乱左侧或右侧背外侧前额叶皮质(DLPFC)的功能，然后应用众所周知的赌博范式，提供风险下决策的衡量标准。在右翼而不是左翼DLPFC被破坏后，个体表现出显著更高的风险决策。我们的发现表明，正确的DLPFC在抑制表面上诱人的选择方面发挥着至关重要的作用。这证实了前额叶皮质在决策中的不对称作用，并揭示了在正常受试者中，这一基本的人类能力可以通过皮质刺激来操纵。改变冒险行为的能力可能会转化为对药物滥用或病态赌博等疾病的治疗干预。
Decisions require careful weighing of the risks and benefits associated with a choice. Some people need to be offered large rewards to balance even minimal risks, whereas others take great risks in the hope for an only minimal benefit. We show here that risk-taking is a modifiable behavior that depends on right hemisphere prefrontal activity. We used low-frequency, repetitive transcranial magnetic stimulation to transiently disrupt left or right dorsolateral prefrontal cortex (DLPFC) function before applying a well known gambling paradigm that provides a measure of decision-making under risk. Individuals displayed significantly riskier decision-making after disruption of the right, but not the left, DLPFC. Our findings suggest that the right DLPFC plays a crucial role in the suppression of superficially seductive options. This confirms the asymmetric role of the prefrontal cortex in decision-making and reveals that this fundamental human capacity can be manipulated in normal subjects through cortical stimulation. The ability to modify risk-taking behavior may be translated into therapeutic interventions for disorders such as drug abuse or pathological gambling.