DRAINAGE OF CEREBRAL INTERSTITIAL FLUID INTO DEEP CERVICAL LYMPH OF THE RABBIT
DRAINAGE OF CEREBRAL INTERSTITIAL FLUID INTO DEEP CERVICAL LYMPH OF THE RABBIT
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DOI：
10.1152/ajprenal.1981.240.4.f329
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发表时间：
1981-01-01
影响因子：
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通讯作者：
WESTROP, RJ
中科院分区：
文献类型：
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作者：
BRADBURY, MWB;CSERR, HF;WESTROP, RJ
连续采集麻醉兔颈静脉干淋巴，在尾状核微量注射1µl~(131)I-白蛋白后、单次脑室注射后和脑室内注射时，测定其中的放射性碘化白蛋白(RISA)。脑内微量注射后7h和25h的淋巴与全脑放射性流出量的比较表明，大约50%的清除放射性是通过淋巴的。脑脊液注射后，淋巴和咽后淋巴结的血药浓度显著高于脑脊液注射或输液后。脑内注射后，注射侧的淋巴结有更多的活动，而脑脊液注射后缺乏偏侧性。计算表明，从大脑中清除的30%的RISA可以通过混合良好的脑脊液做到这一点。组织分析与大量RISA引流是相容的，即通过脑血管周围间隙的大量流动，以及从嗅叶的蛛网膜下腔进入鼻粘膜下间隙，从而进入淋巴。
Lymph from the jugular lymph trunks of anesthetized rabbits was continuously collected and radioiodinated albumin (RISA) therein estimated after microinjection of 1 .mu.l of 131I-albumin into the caudate nucleus, after single intraventricular injections, and during intraventricular infusions. Comparison of lymph at 7 and 25 h after intracerebral microinjection with efflux of radioactivity from whole brain suggests that about 50% of cleared radioactivity goes through lymph. Concentrations, normalized to CSF, were much higher in lymph and retropharyngeal nodes after brain injection than after CSF injection or infusion. After brain injection, lymph nodes contained more activity on injected side in contrast to lack of laterality after CSF administration. Calculation suggests that < 30% of RISA cleared from brain can do so via a pool of well-mixed CSF. Analysis of tissues is compatible with much RISA draining by bulk flow via cerebral perivascular spaces plus passage from subarachnoid space of olfactory lobes into submucous spaces of nose and thus to lymph.