Expansion and drug elution model of a coronary stent
Expansion and drug elution model of a coronary stent
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DOI：
10.1080/10255840601071087
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发表时间：
2007-02-01
影响因子：
1.6
通讯作者：
Dubini, G.
中科院分区：
文献类型：
--
作者：
Migliavacca, F.;Gervasco, F.;Dubini, G.
本研究说明了一种可能的方法来研究药物洗脱从扩张的冠状动脉支架。建立了包含动脉粥样硬化斑块、动脉和冠状动脉支架的有限元模型。这些模型考虑了支架扩张的机械效应以及药物从扩张支架输送到动脉壁的效应。结果允许量化血管壁中的应力场、支架支柱内的组织脱垂以及动脉壁内任何位置和时间的药物浓度，以及药物剂量和药物停留时间等几个相关量。
The present study illustrates a possible methodology to investigate drug elution from an expanded coronary stent. Models based on finite element method have been built including the presence of the atherosclerotic plaque, the artery and the coronary stent. These models take into account the mechanical effects of the stent expansion as well as the effect of drug transport from the expanded stent into the arterial wall. Results allow to quantify the stress field in the vascular wall, the tissue prolapse within the stent struts, as well as the drug concentration at any location and time inside the arterial wall, together with several related quantities as the drug dose and the drug residence times.