An optimized velocity selective arterial spin labeling module with reduced eddy current sensitivity for improved perfusion quantification
An optimized velocity selective arterial spin labeling module with reduced eddy current sensitivity for improved perfusion quantification
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DOI：
10.1002/mrm.24302
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发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
Meakin, James A.;Jezzard, Peter
速度选择性 (VS) 动脉自旋标记是一种很有前途的方法，可通过消除与其他自旋标记技术相关的推注到达延迟来测量缓慢或侧支血流区域的灌注。然而，VS 准备期间的 B0 和 B1 不均匀性以及涡流阻碍了 VS 动脉自旋标记对灌注的准确量化。在这项研究中，通过对健康志愿者的模拟和实验证明，涡流会导致静态组织的错误标记。因此，平均灰质灌注被高估高达 2 倍，具体取决于所使用的 VS 制剂。提出了一种新型八段 B1 不敏感旋转 VS 准备，以减少涡流效应，同时保持先前准备的 B0 和 B1 不敏感性。与之前的两种 VS 制备相比，八段 B1 不敏感旋转对涡流最稳健，并且应该在未来的研究中提高 VS 动脉自旋标记测量的质量和可靠性。 Magn Reson Med，2013。(c) 2012 Wiley periodicals, Inc.
Velocity-selective (VS) arterial spin labeling is a promising method for measuring perfusion in areas of slow or collateral flow by eliminating the bolus arrival delay associated with other spin labeling techniques. However, B0 and B1 inhomogeneities and eddy currents during the VS preparation hinder accurate quantification of perfusion with VS arterial spin labeling. In this study, it is demonstrated through simulations and experiments in healthy volunteers that eddy currents cause erroneous tagging of static tissue. Consequently, mean gray matter perfusion is overestimated by up to a factor of 2, depending on the VS preparation used. A novel eight-segment B1 insensitive rotation VS preparation is proposed to reduce eddy current effects while maintaining the B0 and B1 insensitivity of previous preparations. Compared to two previous VS preparations, the eight-segment B1 insensitive rotation is the most robust to eddy currents and should improve the quality and reliability of VS arterial spin labeling measurements in future studies. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.