Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome
Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome
复制标题
DOI：
10.1194/jlr.p900033-jlr200
复制
发表时间：
2009-09-01
影响因子：
6.5
通讯作者：
Neale, Michael C.
中科院分区：
文献类型：
--
作者：
Elder, Sonya J.;Lichtenstein, Alice H.;Neale, Michael C.
遗传和环境对心血管疾病（CVD）和代谢综合征（MetS）相关因素的相对影响尚不清楚。我们进行了模型拟合分析，以量化与CVD和MetS [腰围，血压，空腹血糖和胰岛素，胰岛素抵抗的稳态模型评估（HOMA-IR）和空腹血脂]相关的因素的遗传，共同的环境和独特的环境方差分量在成年男性和女性单卵双胞胎分开或一起抚养。我们还研究了MetS组件是否具有共同的影响。血浆胆固醇和甘油三酯浓度具有高度遗传性（56- 77%，具有统计学显著性）。腰围、血糖和胰岛素、HOMA-IR和血压具有中度遗传性（43- 57%，统计学显著）。独特的环境因素导致所有变量的方差（20- 38%，具有统计学显著性）。常见的环境因素分别对腰围、收缩压和血糖的变异贡献了23%、30%和42%（统计学显著性）。两个共同的因素影响MetS组分;一个影响除HDL胆固醇外的所有组分，另一个仅影响脂质（甘油三酯和HDL胆固醇）浓度。这些结果表明，遗传方差对与CVD和MetS相关的因素的总方差具有主导影响，并支持MetS的一种或多种潜在病理学的提议。Elder，S. J.，A. H. Lichelman，A. G. Pittas，S. B。Roberts，P. J. Fuss，A. S. Greenberg，M. A. McCrory，T.小J·布沙尔，E. Saltzman和M. C.尼尔遗传和环境对心血管疾病和代谢综合征相关因素的影响J. Lipid Res. 2009. 50：1917-1926。
The relative influence of genetics and the environment on factors associated with cardiovascular disease (CVD) and metabolic syndrome (MetS) remains unclear. We performed model-fitting analyses to quantify genetic, common environmental, and unique environmental variance components of factors associated with CVD and MetS [ waist circumference, blood pressure, fasting plasma glucose and insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and fasting plasma lipids] in adult male and female monozygotic twins reared apart or together. We also investigated whether MetS components share common influences. Plasma cholesterol and triglyceride concentrations were highly heritable (56-77%, statistically significant). Waist circumference, plasma glucose and insulin, HOMA-IR, and blood pressure were moderately heritable (43-57%, statistically significant). Unique environmental factors contributed to the variance of all variables (20-38%, perforce statistically significant). Common environmental factors contributed 23, 30, and 42% (statistically significant) of the variance of waist circumference, systolic blood pressure, and plasma glucose, respectively. Two shared factors influenced MetS components; one influenced all components except HDL cholesterol, another influenced only lipid (triglyceride and HDL cholesterol) concentrations. These results suggest that genetic variance has a dominant influence on total variance of factors associated with CVD and MetS and support the proposal of one or more underlying pathologies of MetS.-Elder, S. J., A. H. Lichtenstein, A. G. Pittas, S. B. Roberts, P. J. Fuss, A. S. Greenberg, M. A. McCrory, T. J. Bouchard, Jr., E. Saltzman, and M. C. Neale. Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome. J. Lipid Res. 2009. 50: 1917-1926.