Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma.
Toll-like receptor 2 is present in the microenvironment of oral squamous cell carcinoma.
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DOI：
10.1038/sj.bjc.6606057
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发表时间：
2011-02-01
影响因子：
8.8
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中科院分区：
文献类型：
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本研究采用免疫组织化学方法检测口腔鳞状细胞癌、上皮不典型增生和刺激性增生组织中Toll样受体2（TLR2）的表达。TLR2在癌和异型增生中的表达明显高于增生（P<0.001）。没有增生的样品显示阳性的角质形成细胞上的TLR2染色，而角质形成细胞在64%的癌和74%的不典型增生的情况下，TLR2阳性。微环境中的阳性TLR2表达表明针对改变的上皮的免疫监视的激活，而恶性角质形成细胞的TLR2表达可能指示对作为促存活机制的细胞凋亡的抗性。
The aim of this study was to investigate the expression of toll-like receptor 2 (TLR2) on cells associated with oral squamous cell carcinoma, epithelial dysplasia and irritative hyperplasia, using immunohistochemistry. More immune cells expressed TLR2 in carcinoma and dysplasia than in hyperplasia (P<0.001). No hyperplastic samples showed positive TLR2 staining on keratinocytes, whereas keratinocytes in 64% of cases of carcinoma and 74% of cases of dysplasia were TLR2 positive. Positive TLR2 expression in the microenvironment suggests activation of immune surveillance against the altered epithelium, whereas TLR2 expression by malignant keratinocytes may be indicative of resistance to apoptosis as a pro-survival mechanism.