Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease.
Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease.
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DOI：
10.1186/s13195-016-0198-6
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发表时间：
2016-07-20
期刊：
影响因子：
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通讯作者：
Taylor JP
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作者：
Blanc F;Colloby SJ;Cretin B;de Sousa PL;Demuynck C;O'Brien JT;Martin-Hunyadi C;McKeith I;Philippi N;Taylor JP
关于路易小体前驱痴呆(PRO-DLB)的脑萎缩模式，我们知之甚少。在这项研究中，我们使用SPM8和指数李代数的不同胚层解剖配准来测量灰质(GM)的体积，并研究DLB前(n = 28)和前驱阿尔茨海默病(PRO-AD)(n = 27)的GM萎缩模式，并将其与老年对照组(n = 33)进行比较(P ≤ 0.05，经家族误差校正)。与对照组相比，PRO-DLB患者双侧胰岛和右侧前扣带回皮质的GM体积减小。阿尔茨海默病前期患者和对照组的GM体积比较显示出更广泛的模式，前者在颞叶(海马区和上、中回)、顶叶和额叶结构的体积减小。前驱症状组的直接比较表明，AD前期患者的顶叶萎缩程度明显高于DLB前期患者。在亲DLB的患者中，我们发现视觉幻觉与左侧楔形核的相对萎缩有关。Pro-DLB的萎缩累及岛叶和前扣带回皮质，这些区域富含von Economo神经元，我们推测这可能与Pro-DLB的早期临床表型有关。
Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer’s disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.