Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry
Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry
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DOI：
10.1136/bmjopen-2018-027535
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发表时间：
2019-06-01
期刊：
影响因子：
2.9
通讯作者：
Lebwohl, Mark
中科院分区：
文献类型：
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作者：
Strober, Bruce;Greenberg, Jeffrey D.;Lebwohl, Mark
目的本分析旨在研究银屑病严重程度（通过体表面积（BSA）评估）与研究者总体评估之间的相关性（伊加;以前只在临床试验中使用），和患者报告的结果（PRO）在现实世界的设置。设计横断面分析内的Corrona Psostrum登记处，一个独立的，前瞻性登记研究。在美国设置70个皮肤科诊所。参与者1529名成年银屑病患者正在接受生物或非生物治疗。截至2016年5月31日的生物系统性银屑病治疗。主要和次要结局指标通过受累BSA的百分比评估银屑病严重程度（轻度（0%-5%）、中度（>5%-10%）、重度（>10%-15%）、非常重度（>15%））和伊加评分（清除/几乎清除（0-1）、轻度（2）、中度（3）、重度（4））。使用方差分析和X-2检验比较BSA和伊加水平的PRO（疼痛、瘙痒、疲劳;皮肤病生活质量指数[DLQI]; EuroQoL视觉焦虑量表[EQ-VAS];工作效率和活动障碍[WPAI]）。银屑病的严重程度和PROs之间的关联进行了检查，使用多变量回归models.Results的平均年龄为50.6岁，47%的患者是女性。与更严重的银屑病一致，症状恶化，DLQI评分增加（p
Objectives This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and the Investigator's Global Assessment (IGA; previously used only in clinical trials), and patient-reported outcomes (PROs) in a real-world setting.Design Cross-sectional analysis within the Corrona Psoriasis Registry, an independent, prospective registry.Setting 70 dermatology practices in the USA.Participants 1529 adult patients with psoriasis being treated with biological or non-biological systemic psoriasis treatment by 31 May 2016.Primary and secondary outcome measures Psoriasis severity was assessed by percentage of affected BSA (mild (0%-5%), moderate (>5%-10%), severe (>10%-15%), very severe (>15%)) and IGA scores (clear/almost clear (0-1), mild (2), moderate (3), severe (4)). PROs (pain, itch, fatigue; Dermatology Life Quality Index [DLQI]; EuroQoL Visual Analogue Scale [EQ-VAS]; Work Productivity and Activity Impairment [WPAI]) were compared across BSA and IGA levels using analysis of variance and X-2 tests. The association between psoriasis severity and PROs was examined using multivariable regression models.Results The mean age was 50.6 years and 47% of patients were female. Consistently with more severe psoriasis, symptoms worsened, DLQI scores increased (p