Motor evoked potential and voluntary EMG activity after olfactory mucosal autograft transplantation in a case of chronic, complete spinal cord injury: case report
Motor evoked potential and voluntary EMG activity after olfactory mucosal autograft transplantation in a case of chronic, complete spinal cord injury: case report
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慢性完全性脊髓损伤病例自体嗅粘膜移植后运动诱发电位和自愿肌电图活动：病例报告
DOI：
10.1038/scsandc.2015.18
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发表时间：
2016
影响因子：
1.2
通讯作者：
Yoshimine T.
中科院分区：
文献类型：
--
作者：
Iwatsuki K;Tajima F;Sankai Y;Ohnishi YI;Nakamura T;Ishihara M;Hosomi K;Ninomiya K;Moriwaki T;Yoshimine T.
嗅觉粘膜自体移植物（OMAs）治疗慢性脊髓损伤（SCI）的疗效已有报道，但尚未有报道通过运动诱发电位（MEPs）的出现记录电生理传导。我们报告了一例39岁的慢性完全性脊髓损伤患者，他在OMA移植后表现出MEPs，经过强化康复，最终能够使用短腿支架和洛夫斯特兰德拐杖行走。最初的伤害发生在1999年11月的一次机动车事故中，导致T8以下感觉运动功能完全丧失。2010年3月进行了损伤部位的OMA移植，并进行了强化的术前和术后康复。患者在移植后96周和144周表现出自主肌电（EMG）活动和MEPs，移植后144周使用短腿支架和Lofstrand拐杖行走。我们能够在OMA后通过强化康复获得mep。据我们所知，这是首个关于慢性完全性脊髓损伤治疗后脊髓电生理电导率恢复的报道。
The efficacy of olfactory mucosal autografts (OMAs) for chronic spinal cord injury (SCI) has been reported, but there is no report documenting electrophysiological conductivity via the emergence of motor evoked potentials (MEPs). We report the case of a 39-year-old man with chronic, complete SCI at T8, who exhibited MEPs after OMA transplantation, and, with intensive rehabilitation, was ultimately able to ambulate with short leg braces and Lofstrand crutches. The initial injury occurred in a motor vehicle accident in November 1999 and resulted in a complete loss of sensorimotor function below T8. OMA transplantation to the injury site was performed in March 2010 in combination with intensive pre-and postoperative rehabilitation. The patient exhibited voluntary electromyograph (EMG) activity and MEPs at 96 and 144 weeks after transplantation and he was was ambulatory with short leg braces and Lofstrand crutches at 144 weeks after transplantation. We were able to elicit MEPs after OMA with intensive rehabilitation. To our knowledge, this is the first report of recovery of electrophysiological conductivity in the spinal cord after any type of treatment for chronic, complete SCI.