NUCLEAR TARGETING SEQUENCES - A CONSENSUS
NUCLEAR TARGETING SEQUENCES - A CONSENSUS
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DOI：
10.1016/0968-0004(91)90184-w
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发表时间：
1991-12-01
影响因子：
13.8
通讯作者：
LASKEY, RA
中科院分区：
文献类型：
--
作者：
DINGWALL, C;LASKEY, RA
核靶向序列对于蛋白质转运到核中是必不可少的。 SV 40大T抗原的7个氨基酸的核靶向序列已被视为模型;然而，许多核靶向序列似乎更复杂。 我们建议在这篇评论中，尽管这种多样性，一个共识的二分基序可以确定。
Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been regarded as the model; however, many nuclear targeting sequences appear to be more complex. We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified.