Glycosylation patterns of mucins in colonic disease
Glycosylation patterns of mucins in colonic disease
复制标题
DOI：
10.1042/bst0230840
复制
发表时间：
1995-11-01
影响因子：
3.9
通讯作者：
Paraskeva, C
中科院分区：
文献类型：
--
作者：
Corfield, AP;Myerscough, N;Paraskeva, C
由衬在胃肠道的粘膜细胞合成和分泌的粘蛋白形成总粘膜分泌的重要部分，从而产生细胞外屏障。粘膜上屏障形成粘膜抵御外部环境攻击的主要防线，包括各种微生物、生化试剂和机械应力。来自胃肠道每个部分的粘蛋白具有典型的碳水化合物和粘蛋白基因产物组成，反映了它们在每个位置的功能[1，2]。分泌的粘蛋白（形成细胞外凝胶[3]）和细胞膜相关（糖萼）粘蛋白（通常为MUC1型并参与细胞表面相互作用[4]）均与胃肠癌和炎症性肠病（如溃疡性结肠炎（UC））期间发生的细胞表面和粘膜上层变化有关[2，5]。此外，由正常肠道细菌植物群分泌的酶以受控的方式持续降解粘膜屏障中的粘蛋白，从而允许在合成、分泌、降解和有效的保护功能之间保持平衡。粘膜屏障粘蛋白结构的改变影响降解速率，从而影响防御屏障的活力。
The mucins synthesized and secreted by the mucosal cells lining the gastrointestinal tract form a vital part of the total mucosal secretion giving rise to the extracellular barrier. The supramucosal barrier forms the primary line of defence for the mucosa against attack from the external environment, including all manner of micro-organisms, biochemical agents and mechanical stresses. Mucins from each section of the gastrointestinal tract have a typical carbohydrate and mucin gene product composition reflecting their function at each location [1, 2]. Both the secreted mucins, forming the extracellular gels [3], and cell membrane-associated (glycocalyx) mucins, typically MUC1 type and involved in cell-surface interactions [4], are implicated in the cell-surface and supramucosal layer changes occurring during gastrointestinal cancer and inflammatory bowel diseases such as ulcerative colitis (UC)[2, 5]. In addition, enzymes secreted by the normal enteric bacterial flora continually degrade mucins in the mucosal barrier in a controlled manner, allowing an equilibrium to be maintained between synthesis, secretion, degradation and an efficient protective function. Modifications in the structure of the mucosal barrier mucins influence the rate of degradation and therefore the viability of the defensive barrier.