Abnormalities of thyroid hormone turnover in patients with diabetes mellitus before and after insulin therapy.
Abnormalities of thyroid hormone turnover in patients with diabetes mellitus before and after insulin therapy.
复制标题
糖尿病患者胰岛素治疗前后甲状腺激素周转异常。
DOI：
--
复制
发表时间：
1979
影响因子：
5.8
通讯作者：
B. K. Preston
中科院分区：
文献类型：
--
作者：
C. Pittman;A. Suda;J. Chambers;H. Mcdaniel;G. Y. Ray;B. K. Preston
本文观察了4例胰岛素依赖型糖尿病和4例胰岛素非依赖型糖尿病患者治疗前后糖代谢异常对甲状腺激素转换的影响。7名正常人作为对照。所有受试者在研究前3周和整个研究期间口服T4（每日0.2 mg）。未治疗和治疗的糖尿病受试者和正常受试者的T4转换结果重叠。然而，在胰岛素治疗后，糖尿病患者的平均游离T4分数和平均游离T4浓度均降低。胰岛素非依赖型和胰岛素依赖型糖尿病患者的T3平均MCR均正常，且不受胰岛素治疗的影响。然而，两组糖尿病患者的平均血清T3浓度、T3处置率和T3转化率均较低。胰岛素治疗后，这些值均增加，但仍显着低于正常受试者。...
Abstract The effects of impaired glucose metabolism on thyroid hormone turnover were studied in four patients with insulin-independent diabetes mellitus and four patients with insulin-dependent diabetes mellitus before and after insulin therapy. Seven normal subjects were included as controls. All subjects were given T4 (0.2 mg daily) by mouth 3 weeks before and throughout the study. T4 turnover results from the untreated and treated diabetic subjects and from the normal subjects overlapped. However, both the mean free T4 fraction and mean free T4 concentration were reduced in the diabetic patients after insulin therapy. The mean MCRs of T3 were normal in both the insulin-independent and the insulin-dependent diabetic patients and were unaffected by insulin therapy. However, the mean serum T3 concentration, T3 disposal rates, and T3 conversion rates were low in both groups of diabetic patients. After insulin therapy, these values all increased but remained significantly lower than in the normal subjects. ...