Triangles bridge the scales: Quantifying cellular contributions to tissue deformation
Triangles bridge the scales: Quantifying cellular contributions to tissue deformation
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DOI：
10.1103/physreve.95.032401
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发表时间：
2017-03-01
影响因子：
2.4
通讯作者：
Julicher, Frank
中科院分区：
文献类型：
--
作者：
Merkel, Matthias;Etournay, Raphael;Julicher, Frank
在这篇文章中，我们提出了一个一般的框架来研究动态和拓扑结构的细胞网络，捕捉二维组织中的细胞包装的几何形状。这种上皮细胞在多细胞生物体的形态发生期间经历大规模变形。大规模的变形来自许多单独的细胞事件，如细胞形状变化，细胞重排，细胞分裂和细胞挤出。使用基于三角形的细胞网络几何表示，我们得到了大规模材料变形的精确分解。有趣的是，我们的方法揭示了细胞旋转和伸长之间的相关性以及细胞生长和伸长对组织变形的贡献。利用这种三角形方法，我们讨论了果蝇蛹翅发育过程中的组织重塑。
In this article, we propose a general framework to study the dynamics and topology of cellular networks that capture the geometry of cell packings in two-dimensional tissues. Such epithelia undergo large-scale deformation during morphogenesis of a multicellular organism. Large-scale deformations emerge from many individual cellular events such as cell shape changes, cell rearrangements, cell divisions, and cell extrusions. Using a triangle-based representation of cellular network geometry, we obtain an exact decomposition of large-scale material deformation. Interestingly, our approach reveals contributions of correlations between cellular rotations and elongation as well as cellular growth and elongation to tissue deformation. Using this triangle method, we discuss tissue remodeling in the developing pupal wing of the fly Drosophila melanogaster.