The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature.
The entorhinal-DG/CA3 pathway in the medial temporal lobe retains visual working memory of a simple surface feature.
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DOI：
10.7554/elife.83365
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发表时间：
2023-03-02
期刊：
影响因子：
7.7
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Xie W;Cappiello M;Yassa MA;Ester E;Zaghloul KA;Zhang W
经典模型将工作记忆（WM）和长期记忆视为由不同神经机制支持的不同心理能力。然而，两种类型的内存所需的计算存在显着的相似之处。例如，精确的特定项目记忆的表示需要分离相似信息的重叠神经表示。这种计算被称为模式分离，它可以由内侧颞叶 (MTL) 的内嗅 DG/CA3 通路介导，以服务于长期情景记忆。然而，尽管最近的证据表明 MTL 参与 WM，但内嗅 DG/CA3 通路在多大程度上支持精确的项目特异性 WM 仍然难以捉摸。在这里，我们将已建立的定向 WM 任务与高分辨率 fMRI 结合起来，以测试内嗅 DG/CA3 通路保留简单表面特征的视觉 WM 的假设。参与者被回顾性地提示在短暂的延迟期间保留所研究的两个方向光栅之一，然后尝试尽可能精确地重现提示的方向。通过对延迟期活动进行建模以重建保留的 WM 内容，我们发现前外侧内嗅皮层 (aLEC) 和海马 DG/CA3 子域都包含与后续回忆保真度相关的项目特定 WM 信息。总之，这些结果凸显了 MTL 电路对特定项目 WM 表示的贡献。
Classic models consider working memory (WM) and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Yet, there are significant parallels in the computation that both types of memory require. For instance, the representation of precise item-specific memory requires the separation of overlapping neural representations of similar information. This computation has been referred to as pattern separation, which can be mediated by the entorhinal-DG/CA3 pathway of the medial temporal lobe (MTL) in service of long-term episodic memory. However, although recent evidence has suggested that the MTL is involved in WM, the extent to which the entorhinal-DG/CA3 pathway supports precise item-specific WM has remained elusive. Here, we combine an established orientation WM task with high-resolution fMRI to test the hypothesis that the entorhinal-DG/CA3 pathway retains visual WM of a simple surface feature. Participants were retrospectively cued to retain one of the two studied orientation gratings during a brief delay period and then tried to reproduce the cued orientation as precisely as possible. By modeling the delay-period activity to reconstruct the retained WM content, we found that the anterior-lateral entorhinal cortex (aLEC) and the hippocampal DG/CA3 subfield both contain item-specific WM information that is associated with subsequent recall fidelity. Together, these results highlight the contribution of MTL circuitry to item-specific WM representation.