INTERACTION OF DIETARY CA, P, MG, MN, CU, FE, ZN AND SE WITH THE ACCUMULATION AND ORAL TOXICITY OF CADMIUM IN RATS
INTERACTION OF DIETARY CA, P, MG, MN, CU, FE, ZN AND SE WITH THE ACCUMULATION AND ORAL TOXICITY OF CADMIUM IN RATS
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DOI：
10.1016/0278-6915(91)90022-y
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发表时间：
1991-04-01
影响因子：
4.3
通讯作者：
VANBLADEREN, PJ
中科院分区：
文献类型：
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作者：
GROTEN, JP;SINKELDAM, EJ;VANBLADEREN, PJ
在喂食含有 30 mg Cd/kg CdCl2 的饮食 8 周的大鼠中检查了 Cd 的毒性。含镉日粮中添加了各种矿物质组合，如钙、磷、镁、锰、铜、铁、锌和硒，以研究这些矿物质组合对镉积累和毒性的保护作用。选择矿物组合以便分析各个成分的影响。 8周喂养期结束时，肝脏和肾皮质中的镉浓度分别为13.9和19.5毫克/千克体重。单独饲喂 30 mg Cd/kg 饲料会导致众所周知的 Cd 效应，例如生长迟缓、轻微贫血、血浆转氨酶活性增加和铁积累改变。只有含有额外铁的补充剂才能显着防止镉积累和毒性。使用钙/磷、铁和锌补充剂获得了最显着的效果，使肝脏和肾脏中的镉积累减少了 70-80%，并降低了镉毒性。矿物组合的保护作用主要是由于 Fe2+ 的存在，但在与 Ca/P 和 Zn 的组合中，Fe 的作用最明显。与Fe2+相比，Fe3+的保护作用明显较低。在两种形式的铁中添加抗坏血酸都改善了铁的吸收，但因此并没有减少镉的积累。因此，饮食中的矿物质状况可能对实验动物中以 CdCl2 形式喂养的镉的积累和毒性有相当大的影响。对于Cd摄入的风险评估，应特别考虑Fe的充足摄入。
The toxicity of Cd was examined in rats fed diets containing 30 mg Cd/kg as CdCl2 for 8 wk. The Cd-containing diets were supplemented with various combinations of the minerals Ca, P, Mg, Mn, Cu, Fe, Zn and Se in order to investigate the protective effect of these mineral combinations on Cd accumulation and toxicity. The mineral combinations were chosen such that the effect of the individual components could be analysed. At the end of the 8-wk feeding period, the Cd concentrations in the liver and renal cortex were 13.9 and 19.5 mg/kg body weight, respectively. The feeding of 30 mg Cd/kg diet alone resulted in well known Cd effects, such as growth retardation, slight anaemia, increased plasma transaminase activities and alteration of Fe accumulation. Only supplements that contained extra Fe resulted in a significant protection against Cd accumulation and toxicity. The most pronounced effect was obtained using a supplement of Ca/P, Fe and Zn, which resulted in a 70-80% reduction in Cd accumulation in the liver and kidneys, as well as a reduction in Cd toxicity. The protective effect of the mineral combinations was mainly due to the presence of Fe2+, but in combinations with Ca/P and Zn the effect of Fe was most pronounced. Compared with Fe2+ the protective effect of Fe3+ was significantly lower. Addition of ascorbic acid to Fe in both forms improved the Fe uptake, but consequently did not decrease Cd accumulation. Thus, the mineral status of the diet may have a considerable impact on the accumulation and toxicity of Cd, fed as CdCl2 in laboratory animals. For the risk assessment of Cd intake, special consideration should be given to an adequate intake of Fe.