Evaluation of quality of life and emotional distress in endometrial cancer patients: A 2-year prospective, longitudinal study
Evaluation of quality of life and emotional distress in endometrial cancer patients: A 2-year prospective, longitudinal study
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DOI：
10.1016/j.ygyno.2014.03.015
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发表时间：
2014-06-01
影响因子：
4.7
通讯作者：
Scambia, Giovanni
中科院分区：
文献类型：
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作者：
Ferrandina, Gabriella;Petrillo, Marco;Scambia, Giovanni
目标.本研究的目的是前瞻性和纵向评估大量子宫内膜癌（EC）患者的生活质量（QoL）和情绪困扰。在诊断时以及术后3、6、12和24个月后进行EORTC QLQ-C30（GHS）、EORTC QLQ-CX 24（CX 24）和医院焦虑抑郁量表（CHAOS）问卷的总体健康状况调查。采用广义线性模型和受试者间检验分析QoL随时间的变化以及各因素与患者QoL之间的相关性。GHS评分随时间推移而改善，但未达到统计学显著性。记录到随着时间的推移，水肿评分恶化，在12个月和24个月评价时有恢复的趋势（p值= 0.028）。月经症状（MS）评分随时间显著恶化，与基线相比，平均值± SE差异达到38.5（p值= 0.011）。性活动（SxA）评分改善，直至12个月评价（p值= 0.048），并显示在末次评估时恢复至基线水平（p值= 0.025）。在3个月评估时记录了焦虑评分的显著改善，并随时间持续改善。在多变量分析中，未婚状态与性活动评分低相关，而与某人同居与MS评分更差相关。月经和水肿症状严重影响EC患者的生活质量。由于社会人口特征在SxA和MS恶化中起着重要作用，因此应将心理社会干预和患者教育视为EC患者治疗的一个组成部分。(C)2014爱思唯尔公司All rights reserved.
Objectives. The aim of the study was to prospectively, and longitudinally, assess Quality of Life (QoL) and emotional distress in a large series of endometrial cancer (EC) patients.Methods. Global Health Status of the EORTC QLQ-C30 (GHS), the EORTC QLQ-CX24 (CX24), and the Hospital Anxiety and Depression Scale CHAOS) questionnaires were administered at diagnosis, and after 3, 6, 12, and 24 months since surgery. The Generalized Linear Model and the Between Subject test were used to analyze QoL changes over time, and the association between factors and patient QoL.Results. GHS scores improved over time, although the statistical significance was not reached. Worse lymphedema scores were documented worsened over time with a trend to recover at the 12- and 24 month evaluation (p-value = 0.028). Scores for Menopausal Symptoms (MS) dramatically worsened over time reaching a 38.5 difference of mean +/- SE compared to baseline (p-value = 0.011). Sexual Activity (SxA) scores improved until the 12-month evaluation (p-value = 0.048), and showed a return to baseline levels at the last assessment (p-value = 0.025). A significant improvement of anxiety scores was documented at the 3-month evaluation, and persisted over time. In multivariate analysis, unmarried status was associated with poor scores for sexual activity, while living with someone was associated with worse MS scores.Conclusions. Menopausal and lymphedema symptoms heavily affect QoL in EC patients. Since socio-demographic features play a major role in deteriorating SxA and MS, psycho-social intervention and patient education should be considered as an integral part of EC patient treatment. (C) 2014 Elsevier Inc. All rights reserved.