Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields.
Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields.
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DOI：
10.1016/j.jconrel.2015.09.038
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发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Kabanov AV
中科院分区：
文献类型：
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作者：
Golovin YI;Gribanovsky SL;Golovin DY;Klyachko NL;Majouga AG;Master АM;Sokolsky M;Kabanov AV
本文介绍了超低频和低频交变磁场中单畴磁性纳米颗粒（MNP）的磁机械驱动的概念及其在纳米医学和药物递送系统的远程控制中的可能用途。远程驱动药物释放以及对生物大分子，生物膜，亚细胞结构和细胞的影响，这种方法的应用进行了讨论相比，采用磁热疗在射频（RF）AMF的传统策略。介绍了几种描述功能化MNP与单个大分子、脂质膜和蛋白质（如细胞膜受体、离子通道）相互作用的定量模型。的MNP和AMF的最佳特性的有效的磁机械驱动的单分子响应在生物和生物启发的系统进行了讨论。总而言之，所描述的研究和现象为单独和与磁热疗结合的新型疗法的开发提供了机会。
The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia.