Neuroglobin and cytoglobin: Genes, proteins and evolution
Neuroglobin and cytoglobin: Genes, proteins and evolution
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DOI：
10.1080/15216540500037257
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发表时间：
2004-11-01
期刊：
影响因子：
4.6
通讯作者：
Hankeln, T
中科院分区：
文献类型：
--
作者：
Burmester, T;Haberkamp, M;Hankeln, T
血红蛋白和肌红蛋白是大多数脊椎动物的氧气运输和储存蛋白质。脑红蛋白(NGB)和细胞球蛋白(Cygb)--脊椎动物珠蛋白超家族的两个新成员--仍有争议的功能。结合所有可用资源的数据，我们研究了这些新的珠蛋白的进化。Ngb和Cygb在脊椎动物进化中都显示出很小的序列变化，这表明它们的结构和功能是保守的，并且在动物的新陈代谢中扮演着重要的角色。外显子-内含子模式在NGB和Cygb中保持不变，除了在哺乳动物进化早期向Cygb增加了一个3‘外显子。在系统发育分析中，NGB与珠蛋白X以及一些无脊椎动物神经珠蛋白形成了一个共同的分支。珠蛋白X是最近发现的另一种在低等脊椎动物中功能不明的珠蛋白。这表明这一分支在动物进化中的早期分歧。Cygb与肌红蛋白有关，与鸟类眼睛特异的珠蛋白有关。珠蛋白的进化模式表明，具有明确呼吸作用的蛋白质是从功能不确定的细胞内珠蛋白独立进化出来的。这一结果表明，要么是多个独立的功能变化，要么是组织球蛋白如NGB和Cygb的呼吸作用尚未确定。
Hemoglobin and myoglobin are oxygen transport and storage proteins of most vertebrates. Neuroglobin (Ngb) and cytoglobin (Cygb)-two recent additions to the vertebrate globin superfamily have still disputed functions. Combining the data from all available resources, we investigate the evolution of these novel globins. Both Ngb and Cygb show little sequence variation in vertebrate evolution, suggesting conserved structures and functions, and an important role in the animal's metabolism. Exon-intron patterns remained unchanged in Ngb and Cygb, with the exception of the addition of a 3' exon to Cygb early in mammalian evolution. In phylogenetic analyses, Ngb forms a common branch with globin X, another recently identified globin with undefined function in lower vertebrates, and with some invertebrate nerve globins. This shows an early divergence of this branch in animal evolution. Cygb is related to myoglobin, and associated with an eye-specific globin from birds. The pattern of globin evolution shows that proteins with clear respiratory roles evolved independently from intracellular globins with uncertain functions. This result suggests either multiple independent functional changes or a yet undefined respiratory role of tissue globins like Ngb and Cygb.