Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants.
Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants.
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DOI：
10.1007/s10995-015-1779-x
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发表时间：
2015-12
影响因子：
2.3
通讯作者：
CIFASD
中科院分区：
文献类型：
--
作者：
Coles CD;Kable JA;Keen CL;Jones KL;Wertelecki W;Granovska IV;Pashtepa AO;Chambers CD;CIFASD
胎儿酒精谱系障碍在弱势群体中更常见。环境因素，如次优营养，可能会加强产前酒精暴露对发育的影响。为了评估包括胆碱在内的微量营养素对减少暴露影响的影响，我们在乌克兰西部的两个OMNI-Net站点（包括高风险和低风险个体）检查了酒精的时间和剂量以及营养补充的影响。饮酒和不饮酒的女性被随机分配到三个复合维生素/矿物质补充剂组：无，复合维生素/矿物质（MVM），复合维生素/矿物质加胆碱。儿童（N = 367）进行了测试，在6个月的贝利量表的婴儿发展（第二次艾德）产生的标准分数的心理发展指数（MDI），精神发育指数（PDI）和行为。广义线性模型用于：（1）酒精组，多种维生素/矿物质和胆碱补充剂的影响的因子分析;（2）检查酒精的量和时间（无水酒精盎司/天[ozAA/天]围怀孕期和平均孕中期）和MVM补充剂对发育结果的关系，同时控制性别，社会阶层和吸烟。MDI受围产期酒精剂量的显著影响（p <.001），酒精越多，得分越低，男性比女性受到的负面影响更大（p < .002）。补充营养素具有保护作用;那些接受补充剂的人表现更好（p <.005）。PDI运动评分在各组之间没有差异，但受围孕期酒精剂量的影响（p <0.04）。补充多种维生素/矿物质可以减少怀孕期间饮酒对特定发育结果的负面影响。
Fetal alcohol spectrum disorders are more common in disadvantaged populations. Environmental factors, like suboptimal nutrition, may potentiate the developmental effects of prenatal alcohol exposure. To evaluate the impact of micronutrients, including choline, on reduction of effects of exposure, we examined timing and dose of alcohol and effects of nutritional supplementation at two OMNI-Net sites in Western Ukraine that included high and low risk individuals. Alcohol-using and nondrinking women were randomized to one of three multivitamin/mineral supplement groups: none, multivitamins/minerals (MVM), and multivitamin/minerals plus choline. Children (N = 367) were tested at 6 months with the Bayley Scales of Infant Development (2nd ED) yielding standard scores for Mental Development Index (MDI), Psychomotor Development Index (PDI) and Behavior. Generalized linear modeling was used: (1) for factorial analysis of effects of alcohol group, multivitamin/minerals, and choline supplementation; and (2) to examine the relationship between amount and timing of alcohol (ounces of absolute alcohol/day [ozAA/day] peri-conception and on average in the second trimester) and MVM supplementation on developmental outcomes while controlling sex, social class, and smoking. MDI was significantly impacted by peri-conceptual alcohol dose ( , p <.001) with more alcohol associated with lower scores and males more negatively affected than females ( , p < .002). Micronutrient supplementation had a protective effect; those receiving supplements performed better ( , p <.005). The PDI motor scores did not differ by group but were affected by peri-conceptual alcohol dose ( , p <.04). Multivitamin/mineral supplementation can reduce the negative impact of alcohol use during pregnancy on specific developmental outcomes.