Genotoxicity in Alzheimer's disease: role of amyloid.
Genotoxicity in Alzheimer's disease: role of amyloid.
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DOI：
10.2174/156720506778249380
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发表时间：
2006-08
影响因子：
2.1
通讯作者：
A. Suram;C. Venugopal;Annamalai Prakasam;K. Sambamurti
中科院分区：
文献类型：
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作者：
A. Suram;C. Venugopal;Annamalai Prakasam;K. Sambamurti
阿尔茨海默病（AD）是一种复杂的神经退行性疾病，病理上以细胞外老年斑（SP）的存在为特征，其蛋白核心由淀粉样肽（Abeta）的聚集体和微管相关蛋白tau （tau）的细胞内聚集体构成神经原纤维缠结（nft）。这些特征包括异常折叠的蛋白质成分，被认为是阿尔茨海默病的神经毒性成分。虽然氧化应激和炎症是毒性的介质，但毒性的机制尚不清楚，而这些损伤反过来又已知会损害细胞成分，包括蛋白质、膜中的脂质和DNA。然而，其遗传毒性及其在AD中的作用尚不清楚。本文讨论了各种影响，特别是淀粉样蛋白，对遗传物质及其在阿尔茨海默病神经退行性变中的可能作用。此外，基因组学和蛋白质组学的融合，以了解阿尔茨海默病和治疗的发展建议。
Alzheimer's disease (AD) is a complex neurodegenerative disorder pathologically identified by the presence of extracellular senile plaques (SP) with a proteinaceous core composed of aggregates of the amyloid peptide (Abeta) and intracellular aggregates of the microtubule-associated protein tau (tau) as neurofibrillary tangles (NFTs). These hallmarks consist of abnormally folded proteinaceous components that are believed to be neurotoxic in AD. The mechanisms of toxicity remain unclear although oxidative stress and inflammation are implicated as mediators of the toxicity and these lesions, in turn, are known to damage cellular components including proteins, lipids in the membrane and DNA. However effects on genotoxicity and its role in AD are less clear. The present review discusses various influences, in particular of amyloid, on the genetic material and their possible role in the neurodegeneration in AD. Further, the amalgamation of genomics and proteomics in understanding AD and therapeutic development is suggested.