Efficient Synthesis of 2,5-Diketopiperazines by Staudinger-Mediated Cyclization
Efficient Synthesis of 2,5-Diketopiperazines by Staudinger-Mediated Cyclization
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DOI：
10.1055/s-0031-1290446
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发表时间：
2012-10-01
期刊：
影响因子：
2
通讯作者：
Katritzky, Alan R.
中科院分区：
文献类型：
--
作者：
Beagle, Lucas K.;Hansen, Finn K.;Katritzky, Alan R.
研究了微波辐射下叠氮基二肽硫酯与杂-2，5-二酮哌嗪的液相和固相Staudinger环化反应。反应时间短，产率高，易于纯化是该方法的主要优点。
Solution- and solid-phase Staudinger-mediated cyclizations were assessed to efficiently prepare hetero-2,5-diketopiperazines from their protected azido dipeptide thioesters under microwave irradiation. Short reaction time, good yields and ease of purification are the main assets of this methodology.