The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
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DOI：
10.1242/dev.00680
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发表时间：
2003-10-01
期刊：
影响因子：
4.6
通讯作者：
Jarman, AP
中科院分区：
文献类型：
--
作者：
Lage, PIZ;Prentice, DRA;Jarman, AP
原神经基因编码神经前体指定所需的碱性-螺旋-环-螺旋(BHLH)转录因子。最近，amos被发现是一个与无机盐相关的新的果蝇神经原基因。在分离了第一个特定的Amos功能丧失突变后，我们明确地表明，Amos需要指定两类嗅觉感受器的前体。与其他已知的神经突变不同，Amos功能丧失的一个新特征是由于scute功能不适当，除嗅觉感受器丧失外，还出现异位感觉刷毛。这支持了原神经基因之间抑制相互作用的模型，在该模型中，类似ATO的基因(AMOS和ATO)必须抑制感觉刷毛的命运，同时促进另一种感觉器官亚型。
Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal. Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute. This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes.