Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study
Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study
复制标题
DOI：
10.1007/s00234-018-2061-x
复制
发表时间：
2018-09-01
期刊：
影响因子：
2.8
通讯作者：
Xue, Yuan
中科院分区：
文献类型：
--
作者：
Chen, Zhao;Wang, Qiu;Xue, Yuan
我们试图利用静息态功能磁共振成像 (rs-fMRI) 研究脊髓型颈椎病 (CSM) 患者视觉皮层神经活动和功能连接 (FC) 的改变，并探讨这些改变与视觉障碍的关系。 招募了 27 名 CSM 患者和 11 名健康对照作为研究组和对照组。计算低频波动幅度（ALFF）和区域均匀性（ReHo）值来代表神经活动，进行基于种子的相关分析（SCA）来分析视觉皮层的FC，并对组间结果进行比较。测量研究组的术前最佳矫正视力（pre-BCVA）和术后BCVA（post-BCVA）。对 ALFF/ReHo 值与术前和术后 BCVA 进行相关分析。比较双侧BCVA与同侧、对侧视觉皮层神经活动的相关性。研究组枕叶ALFF/ReHo值降低，小脑后叶升高（P < 0.05）。 Brodmann 区 17 和后扣带回叶之间的 FC 增加（P < 0.05）。术后，研究组中 22 眼右旋 (OD) 和 20 眼左眼 (OS) 的 BCVA 得到改善。在研究组中检测到视觉皮层神经活动与术前和术后BCVA之间呈正相关。双侧BCVA与同侧或对侧视觉皮层神经活动呈正相关。CSM中显示了ALFF/ReHo值的变化以及这些变化与BCVA的正相关。 CSM 中视觉皮层和后扣带回叶之间的 FC 也增加。
We sought to investigate visual cortex neural activity and functional connectivity (FC) alterations in cervical spondylotic myelopathy (CSM) patients using resting-state fMRI (rs-fMRI) and to explore the relationships of these alterations with visual disorder.Twenty-seven CSM patients and 11 healthy controls were recruited as the study and control groups. The amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) values were calculated to represent neural activity, seed-based correlation analysis (SCA) was performed to analyze the FC of visual cortex, and the outcomes were compared between groups. The preoperative best-corrected visual acuity (pre-BCVA) and postoperative BCVA (post-BCVA) of study groups were measured. Correlation analyses of the ALFF/ReHo values with the preoperative and postoperative BCVAs were performed. Correlations of the bilateral BCVAs with the ipsilateral and contralateral visual cortex neural activities were performed.The ALFF/ReHo values were decreased in the occipital lobe and increased in the cerebellar posterior lobe in the study group (P < 0.05). Increased FC was demonstrated between Brodmann's area 17 and posterior cingulate lobe (P < 0.05). Postoperatively, the BCVAs were ameliorated in 22 oculi dexter (ODs) and 20 oculi sinister (OSs) in the study group. Positive correlations between neural activity in the visual cortex and the preoperative and postoperative BCVAs were detected in the study group. The bilateral BCVAs were positively correlated with either the ipsilateral or contralateral visual cortex neural activity.Both ALFF/ReHo value changes and positive correlations of these changes with BCVA were demonstrated in CSM. The FC between the visual cortex and posterior cingulate lobe was also increased in CSM.