Genetics and chemistry of bacterial flagella
Genetics and chemistry of bacterial flagella
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细菌鞭毛的遗传学和化学
DOI：
10.1128/br.33.4.454-475.1969
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发表时间：
1969
影响因子：
--
通讯作者：
T. Iino
中科院分区：
文献类型：
--
作者：
T. Iino
细菌鞭毛是生物学各个领域研究人员关注的热点。研究细胞运动的生理学家对它们很感兴趣，因为它们是生物体中最简单的运动细胞器。对生化学家来说，细菌鞭毛提供了反映生物活性大分子进化的同工蛋白的丰富来源。细菌鞭毛的形成正成为细胞调控机制和形态发生分子基础研究的独特对象。免疫学家一直在使用细菌鞭毛作为高度特异性和有效的蛋白质抗原，用于抗原决定因子的化学表征以及抗原抗体反应特异性的研究。由于对细菌鞭毛的广泛关注，已经发表了一些综述性文章。因此，本文不打算全面回顾以往关于细菌鞭毛的研究，而是侧重于它们的化学和遗传学，特别是它们的生物合成和形态发生。为了更全面地参考早期的工作，读者可以参考Stocker (182), Weibull（198）和Joys（96）的文章；关于运动性，有Jahn和Bovee（94）和Doetch和Hageage（36）的文章；对于实验技术，Iino和Enomoto（81）和Koffler（114）。
INTRODUCTION Bacterial flagella are attracting the attention of investigators in various fields of biology. Physiologists who are concerned with cellular motility are interested in them as the simplest locomotive organelle in living organisms. To biochemists, bacterial flagella provide a rich source of an isoprotein reflecting the evolution of a biologically active macromolecule. The formation of bacterial flagella is becoming a unique object for studies of both cellular regulatory mechanisms and the molecular basis of morphogenesis. Immunologists have been using bacterial flagella as highly specific and effective protein antigens, for chemical characterization of antigen determinants, and for the studies of the specificity of antigenantibody reactions. Because of the wide interest in bacterial flagella, several review articles on them have already been published. This review, therefore, does not intend to cover past studies on bacterial flagella comprehensively, but rather to focus on their chemistry andgenetics, especially in relation to their biosynthesis and morphogenesis. For more comprehensive references to earlier work, readers may consult the articles by Stocker (182), Weibull (198), and Joys (96); in connection with motility, the articles by Jahn and Bovee (94) and Doetch and Hageage (36); and for the experimental techniques, Iino and Enomoto (81) and Koffler (114).