Desmosome-Ion Channel Interactions and Their Possible Role in Arrhythmogenic Cardiomyopathy
Desmosome-Ion Channel Interactions and Their Possible Role in Arrhythmogenic Cardiomyopathy
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DOI：
10.1007/s00246-012-0257-0
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发表时间：
2012-08-01
影响因子：
1.6
通讯作者：
Delmar, Mario
中科院分区：
文献类型：
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作者：
Delmar, Mario
最常见的是，桥粒蛋白质突变引起的致心律失常性心肌病（也称为致心律失常性右心室心肌病，或ARVC）。问题在于机械连接点的突变影响心脏节律的机制。我们已经提出，一个组成部分的促炎底物可能包括在这两个，缝隙连接和钠通道的功能的变化。在这里，我们回顾了关于这个问题的相关文献。
Most commonly, arrhythmogenic cardiomyopathy (also known as arrhythmogenic right ventricular cardiomyopathy, or ARVC) is caused by mutations in desmosomal proteins. The question arises as to the mechanisms by which mutations in mechanical junctions, affect the rhythm of the heart. We have proposed that a component of the arrhythmogenic substrate may include changes in the function of both, gap junctions and sodium channels. Here, we review the relevant literature on this subject.