Complementation of H-2-linked Ir genes in the mouse.
Complementation of H-2-linked Ir genes in the mouse.
复制标题
小鼠中 H-2 连接的 Ir 基因的互补。
DOI：
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发表时间：
1975
影响因子：
11.1
通讯作者：
B. Benacerraf
中科院分区：
文献类型：
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作者：
M. Dorf;B. Benacerraf
小鼠对L-谷氨酸、L-赖氨酸和L-苯丙氨酸（GLphi）的随机线性突变的免疫应答受显性H-2连锁Ir基因控制。两个非应答菌株之间的交配产生了应答F1杂交种，证明了非应答等位基因的互补。这一观察结果，再加上几个内部H-2重组菌株之间的重组两个无应答亲本单倍型也是GLphi反应，表明至少有两个显性基因座与这种突变的反应。互补基因被称为α（暂时定位于H-2复合物的一个新亚区，I-F）和β，它映射在I-A亚区。通常，α（+）和β（+）等位基因都是反应性所需的。然而，在（C57 BL/6 J X SJL）F1杂种中，我们注意到两个亲本无应答菌株之间的互补，每个菌株携带来自不同H-2单倍型的β基因，但缺乏功能性α基因。可能的细胞水平，这些基因可能发挥作用的免疫反应的调节进行了讨论。
The immune response to the random linear terpolymer of L-glutamic acid, L-lysine, and L-phenylalanine (GLphi) is under dominant H-2-linked Ir gene control in the mouse. Matings between two nonresponder strains produced responder F1 hybrids, demonstrating complementation of the nonresponder alleles. This observation, coupled with the fact that several intra H-2 recombinant strains derived by recombination between two nonresponder parental haplotypes are also GLphi responders, indicated at least two dominant loci are concerned with responsiveness to this terpolymer. The complementary genes were termed alpha (tentatively localized in a new subregion of the H-2 complex, I-F) and beta, which maps in the I-A subregion. Generally, both the alpha(+) and beta(+) alleles are required for responsiveness. However, in the (C57BL/6J X SJL)F1 hybrid we noted complementation between two parental nonresponder strains, each of which carried beta genes derived from different H-2 haplotypes, yet lacked functional alpha genes. The possible cell levels at which these genes may function in the regulation of the immune response are discussed.