Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR‐IC within the human spinal cord
Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR‐IC within the human spinal cord
复制标题
人脊髓内新型 mu 阿片受体剪接变体 MOR-IC 羧基末端的免疫组织化学定位
作者：
C. Abbadie;Gultekin Sh;G. Pasternak
本研究检测了MOR-IC中一个独特的羧基末端序列在人类脊髓中的分布，MOR-IC是最近描述的克隆的mu阿片受体基因MOR-I的剪接变体之一。尽管仅在浅层中观察到mor - i样免疫反应性（LI）和δ阿片受体样免疫反应性，但MOR-IC-LI在背角浅层和中央管周围大量存在。在明胶质中，小直径轴突元件、小脊髓神经元细胞质和质膜、内II层树突和利索束内部分纤维中均可见到mori - ic - li。这些研究表明morc - ic存在于人类脊髓中，其分布表明它在疼痛加工的控制中起作用。
The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-IC, one of the recently described splice variants of the cloned mu opioid receptor gene MOR-I. Although MOR-I-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were observed only in the superficial laminae, MOR-IC-LI was abundant in the superficial laminae of the dorsal horn and around the central canal. In the substantia gelatinosa, MOR-IC-LI was found in small diameter axonal elements, the cytoplasm and the plasmalemma of small spinal neurons and dendrites in inner lamina II and in some fibers within Lissauer's tract. These studies imply the presence of MOR-IC in human spinal cord and its distribution suggests that it plays a role in the control of pain processing.