Antimicrobial-Polyacetylenes from Panax ginseng Hairy Root Culture
Antimicrobial-Polyacetylenes from Panax ginseng Hairy Root Culture
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DOI：
10.1248/cpb.60.377
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发表时间：
2012-03-01
影响因子：
1.7
通讯作者：
Orihara, Yutaka
中科院分区：
文献类型：
--
作者：
Fukuyama, Noriaki;Shibuya, Masaaki;Orihara, Yutaka
从人参毛状根培养物中分离出两种新的聚乙炔：1-羟基二氢人参醇 (3) 和 17-羟基人参醇 (4)，以及二氢人参醇 (1)、人参醇 (2) 和人参皂苷 D (5)。从培养基中分离出高度羟基化的化合物1-4，并从根中分离出化合物5，化合物5是化合物1的生物合成前体。化合物1-4对金黄色葡萄球菌、枯草芽孢杆菌、新型隐球菌和烟曲霉具有抗菌活性。有人建议，人参植物从根部将抗菌聚乙炔作为防御化合物释放到周围土壤中。
Two new polyacetylenes, 1-hydroxydihydropanaxacol (3) and 17-hydroxypanaxacol (4), were isolated from Panax ginseng hairy root culture, along with dihydropanaxacol (1), panaxacol (2) and ginsenoyne D (5). Highly hydroxylated compounds 1-4 were isolated from the medium and compound 5, which was a biosynthetic precursor of compound 1, was isolated from the roots. Compounds 1-4 showed antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Cryptococcus neoformans and Aspergillus fumigatus. It is suggested that P. ginseng plants release antimicrobial polyacetylenes into the surrounding soil from the roots as defense compounds.