Spermatogenic function of the testis.
Spermatogenic function of the testis.
复制标题
睾丸的生精功能。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
A. Steinberger
中科院分区：
文献类型：
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作者：
E. Steinberger;A. Steinberger
讨论了睾丸的生精功能。大部分讨论主要基于从大鼠实验中获得的数据。回顾了睾丸的基本结构和发育。定义并概述了生精上皮的周期。生发上皮增殖的机制似乎是自我更新生发干细胞的原理。干细胞分裂导致形成额外的干细胞，这些干细胞在下一个周期之前保持“休眠”状态，并形成A型精原细胞，进入生精过程并最终转化为成熟的精子。讨论了精子发生过程的动力学和精子发生的持续时间。讨论了支持细胞的吞噬活性。研究结果表明，成年睾丸中的支持细胞群是稳定的。然而，据报道，人类睾丸生精小管中支持细胞的分布缺乏均匀性，并且不同个体睾丸中这些细胞的绝对数量存在显着差异。
Spermatogenic function of the testis is discussed. The bulk of discussion is based heavily on data obtained from experiments on the rat. The basic structure and development of the testes are reviewed. The cycle of the seminiferous epithelium is defined and outlined. The mechanism responsible for germinal epithelium proliferation appears to be the principle of a self-renewing germinal stem cell. The stem-cell divisions result in formation of additional stem cells which remain "dormant" until the subsequent cycle and in the formation of Type A spermatogonia which enter the spermatogenic process and ultimately are transformed into mature spermatozoa. The kinetics of the spermatogenic process and the duration of spermatogenesis are discussed. The phagocytic activity of the Sertoli cells are discussed. Findings suggest that the Sertoli cell population in the adult testes is stable. However a lack of uniformity of distribution of Sertoli cells in the seminiferous tubules of human testis and marked variation in the absolute numbers of these cells in testes of different individuals have been reported.