Neighborhood deprivation is associated with lower levels of serum carotenoids among adults participating in the third national health and nutrition examination survey
Neighborhood deprivation is associated with lower levels of serum carotenoids among adults participating in the third national health and nutrition examination survey
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DOI：
10.1016/j.jada.2007.08.016
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发表时间：
2007-11-01
影响因子：
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通讯作者：
Eschbach, Karl
中科院分区：
文献类型：
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作者：
Stimpson, Jim P.;Nash, Anita C.;Eschbach, Karl
目的本研究验证了与富裕居民区相比，社区剥夺与血清类胡萝卜素水平较低相关的假设。研究对象为第三次全国健康与营养检查调查的17002名17岁及以上的参与者，与1990年人口普查数据相关联。主要结果测量番茄红素、β-胡萝卜素、α-胡萝卜素、叶黄素/玉米黄质和β-隐黄质的血清水平。统计分析多元线性回归用于模拟血清类胡萝卜素和邻里剥夺的关联，这是一个用于区域水平社会经济地位的11个指标的汇总指数。对个体水平的年龄、性别、受教育年限、家庭收入、就业、种族/民族、体重指数、血清可替宁、饮酒、体力活动和血清胆固醇进行了调整。结果多变量分析显示，高水平的邻里剥夺与P-胡萝卜素之间存在负相关和统计学显著性（β =-2.98 μ g/dL [-0.06 μ mol/L]，P=0.00），α-胡萝卜素（β =-1.28 μ g/dL [-0.02 μ mol/L]，P=< 0.0001），叶黄素/玉米黄质（-1.69 μ g/dL [-0.03 μ mol/L]，P=0.00），P-隐黄质（β =-1.34 μ g/dL [-0.02 μ mol/L]，P < 0.0001）和总类胡萝卜素（β =-8.20 μ g/dL，P=< 0.0001）。番茄红素与邻里剥夺无关。高剥夺社区的类胡萝卜素调整后的平均水平低于低剥夺社区：β-胡萝卜素=8.72 μ g/dL，[0.16 μ mol/L]对20.64 μ g/dL [0.38 μ mol/L]，α-胡萝卜素=0.44 μ g/dL [0.008 μ mol/L]对5.56 μ g/dL [0.10 μ mol/L]，叶黄素/玉米黄质= 13.79 μ g/dL [0.24 μ mol/L]对20.55 μ g/dL [0.36 μ mol/L]，β-隐黄质4.57 μ g/dL [0.08 μ mol/L]对9.93 μ g/dL [0.18 μ mol/L]，番茄红素=22.07 μ g/dL [0.41 μ mol/L] vs 25.63 μ g/dL [0.48 μ mol/L]，总=49.56 μ g/dL vs 82.36 μ g/dL。在水果和蔬菜摄入量方面，低贫困和高贫困居民区之间存在着巨大的差距。
Objective This study tested the hypothesis that neighborhood deprivation will be associated with lower levels of serum carotenoids in comparison with wealthy residential areas.Design Cross-sectional, nationally representative survey data were used to assess the relationship between neighborhood level socioeconomic status and serum carotenoids.Subjects Seventeen thousand two participants aged 17 years and older from the Third National Health and Nutrition Examination Survey were linked with 1990 census data.Main outcome measures Serum levels of lycopene, beta-carotene, alpha-carotene, lutein/zeaxanthin, and beta-cryptoxanthin.Statistical analysis Multivariate linear regression was used to model the association of serum carotenoids and neighborhood deprivation, which is a summary index of 11 indicators for tract level socioeconomic status. Adjustments are made for individual level age, sex, years of education, household income, employment, race/ethnicity, body mass index, serum cotinine, alcohol use, physical activity, and serum cholesterol.Results Multivariate analysis revealed a negative and statistically significant association between high levels of neighborhood deprivation and P-carotene (beta=-2.98 mu g/dL [-0.06 mu mol/L], P=0.00), a-carotene (beta=-1.28 mu g/dL [-0.02 mu mol/L], P=< 0.0001), lutein/zeaxanthin (-1.69 mu g/dL [-0.03 mu mol/L], P=0.00, P-cryptoxanthin (beta=-1.34 mu g/dL [-0.02 mu mol/L], P < 0.0001), and total carotenoids (beta=-8.20 mu g/dL, P=< 0.0001). Lycopene was not related to neighborhood deprivation. Adjusted mean levels of carotenoids for high deprivation neighborhoods were lower than neighborhoods with low deprivation: beta-carotene=8.72 mu g/dL, [0.16 mu mol/L] vs 20.64 mu g/dL [0.38 mu mol/L], alpha-carotene=0.44 mu g/dL [0.008 mu mol/L] vs 5.56 mu g/dL [0.10 mu mol/L], lutein/zeaxanthin= 13.79 mu g/dL [0.24 mu mol/L] vs 20.55 mu g/dL [0.36 mu mol/L], beta-cryptoxanthin 4.57 mu g/dL [0.08 mu mol/L] vs 9.93 mu g/dL [0.18 mu mol/L], lycopene=22.07 mu g/dL [0.41 mu mol/L] vs 25.63 mu g/dL [0.48 mu mol/L], and total=49.56 mu g/dL vs 82.36 mu g/dL.Conclusions Neighborhood deprivation was associated with lower serum levels of carotenoids. There was a substantial disparity between low deprivation and high deprivation residential areas with respect to fruit and vegetable intake.