Occupational exposure to solar ultraviolet radiation and the risk of prostate cancer
Occupational exposure to solar ultraviolet radiation and the risk of prostate cancer
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DOI：
10.1136/oemed-2016-103567
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发表时间：
2016-11-01
影响因子：
4.9
通讯作者：
Koehoorn, Mieke W.
中科院分区：
文献类型：
--
作者：
Peters, Cheryl E.;Demers, Paul A.;Koehoorn, Mieke W.
目标 对前列腺癌可预防的危险因素知之甚少；阳光照射是一个可能的保护因素。本研究的目的是调查户外工作者（即经常暴露在阳光下的人群）患前列腺癌的风险。方法本分析使用了一项大型研究（1994 年至 1997 年进行）中的前列腺癌病例和对照。使用工作暴露矩阵 (JEM) 将工作中的太阳紫外线辐射 (UVR) 指定为中等（2 至 = 6 小时）。平均每日卫星 UV-B 测量值与每个参与者居住地的纬度/经度相关。还检查了其他几个暴露指标，包括曾经/从未暴露和标准红斑剂量（SEDxyears）。使用Logistic回归来评估太阳UVR暴露与前列腺癌几率之间的关联。结果总共纳入1638例病例和1697例对照。与白种人男性相比，印度裔和亚裔男性患前列腺癌的几率降低（OR分别为0.17（0.08至0.35）和0.25（0.15至0.41）），与已婚男性相比，单身男性（OR为0.76（0.58至0.98））也是如此。总体而言，除一例外，阳光照射与前列腺癌之间没有观察到统计学上的显着关联。在仅考虑高类别工作暴露的卫星增强 JEM 中，与未暴露的男性相比，累积暴露最高四分位的男性患前列腺癌的几率降低（OR 0.68（0.51 至 0.92））。 结论 这项研究发现与前列腺癌相关的证据有限，但有一项统计显着的发现除外，即长期暴露在阳光下时间最长和最高的工人的风险降低。
Objectives Preventable risk factors for prostate cancer are poorly understood; sun exposure is a possible protective factor. The goal of this study was to investigate prostate cancer risk in outdoor workers, a population with high sun exposure.Methods Prostate cancer cases and controls from a large study (conducted between 1994 and 1997) were used for this analysis. A job exposure matrix (JEM) was used to assign solar ultraviolet radiation (UVR) at work as moderate (2 to = 6 hours). Average daily satellite UV-B measures were linked to the latitude/longitude of the residences of each participant. Several other exposure metrics were also examined, including ever/never exposed and standard erythemal dose by years (SEDxyears). Logistic regression was used to evaluate the association between solar UVR exposure and the odds of prostate cancer.Results A total of 1638 cases and 1697 controls were included. Men of Indian and Asian descent had reduced odds of prostate cancer (ORs 0.17 (0.08 to 0.35) and 0.25 (0.15 to 0.41), respectively) compared with Caucasian men, as did single men (OR 0.76 (0.58 to 0.98)) compared with married men. Overall, no statistically significant associations were observed between sun exposure and prostate cancer with 1 exception. In the satellite-enhanced JEM that considered exposure in high category jobs only, prostate cancer odds in the highest quartile of cumulative exposure was decreased compared with unexposed men (OR 0.68 (0.51 to 0.92)).Conclusions This study found limited evidence for an association with prostate cancer, with the exception of 1 statistically significant finding of a decreased risk among workers with the longest term and highest sun exposure.