Association of individual-level concentrations and human respiratory tract deposited doses of fine particulate matter with alternation in blood pressure
Association of individual-level concentrations and human respiratory tract deposited doses of fine particulate matter with alternation in blood pressure
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细颗粒物的个体浓度和人体呼吸道沉积剂量与血压变化的关系
DOI：
10.1016/j.envpol.2017.07.006
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发表时间：
2017
影响因子：
8.9
通讯作者：
Yuan Jing
中科院分区：
文献类型：
--
作者：
Yin Wenjun;Hou Jian;Xu Tian;Cheng Juan;Wang Xiaoying;Jiao Shilin;Wang Lin;Huang Cheng;Zhang Youjian;Yuan Jing
细颗粒物（PM2.5）会增加心血管事件的风险，部分原因是它在人体呼吸道中的沉积。为探讨大气PM2.5暴露对血压变化的短期影响，本研究于2014 - 2015年冬夏季进行。研究对象为武汉市106名社区居民。我们在每个季节重复监测家庭和室外PM2. 5浓度以及个人水平的PM2. 5，然后使用不同的方法（如使用剂量学模型）评估个人PM2. 5暴露（包括人体呼吸道中的PM2. 5沉积剂量）。所有受试者均参加体格检查，包括炎症指标、血压和肺功能参数的测量。随后，我们使用广义加性模型评估了暴露于PM2.5的健康损害。我们观察到在2天的滞后期内，环境固定场所、家庭、个人水平的PM2.5暴露以及每个暴露浓度的相应肺沉积剂量的四分位数范围增加，血压升高（p< 0.05），各暴露浓度的四分位数间距增加，使BP在3天后下降（p <0.05），而四分位数间距增加，使肺沉积剂量增加（p< 0.05）。本研究中通过沉积分数估计的PM2.5沉积剂量与以前报道的方法参考的沉积分数相当，与BP的变化相关。结论：肺内PM2.5沉积量可作为评价全身性炎症对心血管系统不良反应的定量指标。然而，我们需要仔细评估急性心血管不良反应，使用周围的固定位置的PM2.5短期暴露后的PM2.5。
Fine particulate matter (PM2.5) contributes to the risk of cardiovascular events, partially owing to its deposition in the human respiratory tract. To investigate short-term effects of ambient PM2.5exposure on alternation of blood pressure (BP), this study was conducted during the winter-summer period between 2014 and 2015. The study included 106 community residents in Wuhan city, China. We repeatedly monitored the household and outdoor PM2.5concentrations as well as individual-level PM2.5in each season, and then assessed personal PM2.5exposure (including deposited doses of PM2.5in the human respiratory tract) by using different methodology (such as using a dosimetry model). All participants took part in the physical examination, including the inflammatory indicators, BP and lung function parameters measurements. Subsequently, we assessed the health damage of exposure to PM2.5using generalized additive models. We observed increased BP at 2-day lag for an interquartile range increase in ambient fixed-site, households, individual-level PM2.5exposure and the corresponding lung deposited doses of each exposure concentration (p< 0.05), decreased BP at 3-day lag for an interquartile range increase in ambient fixed-site, households PM2.5and the corresponding lung deposited doses of each exposure concentration (p< 0.05). The estimated deposited doses of PM2.5by the deposition fractions in this study and the referenced deposition fractions by previous reported method were equivalent associated with alternation in BP. In conclusion, lung deposited dose of PM2.5as a quantitative indicator may be used to assess adverse cardiovascular effects following the systemic inflammation. However, we require careful assessment of acute adverse cardiovascular effects using ambient fixed-site PM2.5after short-term PM2.5exposure.