The structure of human-plasma low-density lipoprotein B. An X-ray small-angle scattering study.
The structure of human-plasma low-density lipoprotein B. An X-ray small-angle scattering study.
复制标题
人血浆低密度脂蛋白 B 的结构。X 射线小角散射研究。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
G. Kostner
中科院分区：
文献类型：
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作者：
K. Müller;P. Laggner;O. Glatter;G. Kostner
1.本文报道了人血浆脂蛋白低密度组分（ρ = 1.016- 1.060 g·cm ~（-3））B在不同电子密度衬度下的X射线小角散射。2.颗粒的整体结构的特征在于准球形形状和径向对称。测得其最大粒径为23 nm，分子量为2.4 × 10 ~（6）。3.内部结构的描述中的一个模型组成的球形层具有不同的电子密度，表明中性脂质被安排在核心的分子由单层的游离胆固醇，磷脂和蛋白质包围的半径约为8 nm。神经脂质被证明是在一个有序的，液晶状态在4摄氏度，并在更高的温度下进行热致转变成无序状态。
1. X-ray small-angle scattering of human plasma lipoprotein B of the low-density fraction (rho = 1.016--1.060 g.cm-3) has been recorded to high precision at different electron density contrasts. 2. The overall structure of the particles is characterized by a quasi-spherical shape and radial symmetry. A maximum diameter of 23 nm and a molecular weight of 2.4 X 10(6) have been determined. 3. The internal structure is described in terms of a model consisting of spherical layers with different electron densities indicating that the neutral lipids are arranged in the core of the molecule up to a radius of about 8 nm surrounded by a monolayer of free cholesterol, phospholipids and protein. The neural lipids are shown to be in an ordered, liquid crystalline state at 4 degrees C and to undergo a thermotropic transition into a disordered state at higher temperatures.