Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol
Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol
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DOI：
10.1080/08927014.2011.553282
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发表时间：
2011-01-01
期刊：
影响因子：
2.7
通讯作者：
Nogata, Yasuyuki
中科院分区：
文献类型：
--
作者：
Kitano, Yoshikazu;Akima, Chika;Nogata, Yasuyuki
合成了二十种源自香茅醇的新型简单烷基异氰化物，并评估了它们对藤壶鲤鱼幼虫（Balanus amphitrite）的防污活性和毒性。合成的异氰化物的抗藤壶活性的EC50范围为0.08-1.49 g ml-1。含有苯甲酸酯和氯基团的简单异氰化物显示出最有效的抗藤壶活性。此外，合成的化合物均未表现出明显的毒性，LC50值为10 g ml-1。几乎所有合成化合物的LC50/EC50比值为102。结果表明这些简单的异氰化物是有前途的低毒防污剂。
Twenty novel simple alkyl isocyanides derived from citronellol were synthesized and evaluated for their antifouling activity and toxicity against cypris larvae of the barnacle, Balanus amphitrite. The anti-barnacle activity of the synthesized isocyanides was in the EC50 range of 0.08-1.49 g ml-1. Simple isocyanides containing a benzoate and chloro group showed the most potent anti-barnacle activity. In addition, none of the synthesized compounds showed significant toxicity and LC50 values were 10 g ml-1. The LC50/EC50 ratios of almost all of the synthesized compounds were 102. The results indicate that these simple isocyanides are promising low-toxicity antifouling agents.