OG4C3 CIRCULATING ANTIGEN - A MARKER OF INFECTION AND ADULT WORM BURDEN IN WUCHERERIA-BANCROFTI FILARIASIS
OG4C3 CIRCULATING ANTIGEN - A MARKER OF INFECTION AND ADULT WORM BURDEN IN WUCHERERIA-BANCROFTI FILARIASIS
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DOI：
10.1093/infdis/170.1.247
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发表时间：
1994-07-01
影响因子：
6.4
通讯作者：
CARTEL, JL
中科院分区：
文献类型：
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作者：
CHANTEAU, S;MOULIAPELAT, JP;CARTEL, JL
94.5%（259/274）的微丝蚴血症者、32%（239/751）的疑似丝虫病者和23%（11/48）的慢性丝虫病患者血清中检测到Og 4C 3循环抗原。抗原水平与微丝蚴密度和患者年龄相关（P <0.01）。在使用杀微丝蚴药物治疗的患者中保持稳定。Og 4C 3抗原在Mf培养基中检测不到，被证明是罕见的体细胞Mf抗原。它似乎是丝虫成虫排泄或分泌的抗原。它可以作为感染的标志物和成虫负荷的指标。
Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.